{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:38:35Z","timestamp":1785515915093,"version":"3.56.0"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a rare case of congenital syphilis (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) presenting as <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>arisch\u2013<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>erxheimer reaction (<jats:styled-content style=\"fixed-case\">JHR<\/jats:styled-content>) at birth. The mother (primigravida) presented in labor and had not received antenatal care. She was given prophylactic ampicillin 2\u2009g i.v. on admission and delivered shortly thereafter. The male infant (2899\u2009g) had normal vital signs, conjunctival congestion, splenohepatomegaly, and maculopapular rash with small blisters over the entire body. Serological tests on the infant and mother confirmed <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>. The infant was given i.v. ampicillin for 14\u2009days (50\u2009mg\/kg per day until\u2009day 3, 100\u2009mg\/kg per day thereafter). One\u2009hour after the first injection, the infant developed fever (39\u00b0C), tachycardia and tachypnea without worsening of rash. Vital signs improved gradually. The rash reduced markedly at postnatal day 1, and disappeared without pigmentation at day 3. This was considered a <jats:styled-content style=\"fixed-case\">JHR<\/jats:styled-content> following ampicillin injection given to the mother before delivery and to the infant after birth.<\/jats:p>","DOI":"10.1111\/ped.12417","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T02:58:05Z","timestamp":1428980285000},"page":"299-301","source":"Crossref","is-referenced-by-count":11,"title":["Congenital syphilis presenting as <scp>J<\/scp>arisch\u2013<scp>H<\/scp>erxheimer reaction at birth"],"prefix":"10.1111","volume":"57","author":[{"given":"Hideyuki","family":"Hori","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ota Memorial Hospital  Gumma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitake","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ota Memorial Hospital  Gumma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tosiji","family":"Shitara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ota Memorial Hospital  Gumma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0900-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2005.06.005"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G308"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2005.00631.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0755-7.00210-4"},{"key":"e_1_2_5_7_1","first-page":"1238","article-title":"Cerebrospinal fluid penetration of antibiotics and chemotherapy","volume":"17","author":"Haruta T","year":"2001","journal-title":"Antibiot. Chemother."}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:59:19Z","timestamp":1695981559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ped.12417"],"URL":"https:\/\/doi.org\/10.1111\/ped.12417","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}