{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:15:00Z","timestamp":1759421700831},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kawano Masanori Memorial Foundation for Promotion of Pediatrics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Angiotensinogen (AGT<\/jats:styled-content><\/jats:italic>) and angiotensin\u2010converting enzyme (ACE<\/jats:styled-content><\/jats:italic>) are recognized as important regulators of body mass index (BMI<\/jats:styled-content>) and systemic blood pressure (BP<\/jats:styled-content>). An association between these single nucleotide polymorphisms (SNP<\/jats:styled-content>) of AGT<\/jats:styled-content><\/jats:italic> and ACE<\/jats:italic><\/jats:styled-content> genes and obesity or hypertension has been established. This study examined relationships between the molecular variants of the AGT<\/jats:styled-content><\/jats:italic> and ACE<\/jats:styled-content><\/jats:italic> genes and bodyweight or BP<\/jats:styled-content> in children treated with glucocorticoids for nephrotic syndrome.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty J<\/jats:styled-content>apanese children (male, n<\/jats:italic> = 14; female, n<\/jats:italic> = 6; age, 2\u201313\u2009years) were genotyped for AGT<\/jats:styled-content><\/jats:italic> polymorphisms (M235T<\/jats:styled-content><\/jats:italic> and A\u20106G<\/jats:styled-content><\/jats:italic>) and the ACE<\/jats:styled-content><\/jats:italic> polymorphisms (insertion\/deletion: I<\/jats:styled-content>\/D<\/jats:styled-content><\/jats:italic> and rs4341<\/jats:italic>). All of the children studied were treated with daily prednisolone 2\u2009mg\/kg for 4\u2009weeks and thereafter alternate\u2010day prednisolone for 8\u2009weeks. BMI<\/jats:styled-content>, BMI<\/jats:styled-content> z\u2010scores, blood lipids, renal function and BP<\/jats:styled-content> in each group were evaluated during the study period.<\/jats:p><\/jats:sec>Results<\/jats:title>BMI<\/jats:styled-content> and BMI<\/jats:styled-content> z\u2010scores during the glucocorticoid therapy were significantly higher in the TT<\/jats:styled-content><\/jats:italic> genotype of the AGT M235T<\/jats:styled-content><\/jats:italic> polymorphisms and the AA<\/jats:styled-content><\/jats:italic> genotype of the AGT<\/jats:styled-content> A\u20106G<\/jats:italic> polymorphisms compared to other genotypes (P<\/jats:italic> < 0.05). In contrast, the molecular variant of ACE I<\/jats:styled-content>\/D<\/jats:italic> and rs4341<\/jats:italic> genotypes did not change bodyweight during the glucocorticoid exposure. It was evident, however, that the BP<\/jats:styled-content> and blood lipids and renal function were not significantly influenced by the AGT<\/jats:styled-content><\/jats:italic> and ACE<\/jats:styled-content><\/jats:italic> polymorphisms.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The TT<\/jats:styled-content><\/jats:italic> genotype of the AGT M235T<\/jats:styled-content><\/jats:italic> and the AA<\/jats:styled-content><\/jats:italic> genotype of the A\u20106G<\/jats:styled-content><\/jats:italic> polymorphisms may predispose children to bodyweight gain when initially treated with glucocorticoids for nephrotic syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12434","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T06:15:33Z","timestamp":1404281733000},"page":"72-78","source":"Crossref","is-referenced-by-count":3,"title":["Genotypes of the renin\u2013angiotensin system and glucocorticoid complications"],"prefix":"10.1111","volume":"57","author":[{"given":"Akio","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Paediatrics Teikyo University School of Medicine Tokyo Japan"},{"name":"Department of Paediatrics Social Insurance Omiya General Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030871"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.3.402"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343677"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00053-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314315"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2008.12.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00218-8"},{"key":"e_1_2_6_9_1","first-page":"521","article-title":"Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese","volume":"8","author":"Kamitani A","year":"1994","journal-title":"J. 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