{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:23:19Z","timestamp":1761765799763},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several reports have shown the beneficial effects of early or prophylactic surfactant therapy for preterm infants, who often develop respiratory distress syndrome. No report, however, has addressed which infants should receive surfactant therapy in the delivery room. Therefore, the aim of this study was to assess the validity of identifying infants who need surfactant therapy based on fraction of inspiratory oxygen (<jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content>) requirement in the delivery room.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this observational, retrospective study, <jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> given in the delivery room, use of surfactant therapy, stable microbubble test (<jats:styled-content style=\"fixed-case\">SMT<\/jats:styled-content>) results, and changes in <jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> both before and after surfactant therapy were reviewed in infants born at &lt;33 weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 170 infants were included. Forty infants were given oxygen with <jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> \u22650.6, and all received surfactant therapy. Of these 40 infants, <jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> could be reduced in 36 (90%) by an average of 0.46 after surfactant therapy. <jats:styled-content style=\"fixed-case\">SMT<\/jats:styled-content> was done in 22 of 40 infants, and surfactant insufficiency was suspected in 20 (91%). In contrast, 81 of 102 infants (79%) with <jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> &lt;0.4 did not need surfactant therapy within 48\u2009h after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preterm infants who need <jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> \u22650.6 in the delivery room appear to be at high risk of surfactant insufficiency and would benefit from surfactant. Surfactant therapy would provide a more effective resuscitation method for preterm infants, and thus a larger prospective study is needed to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12435","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:21:56Z","timestamp":1404260516000},"page":"55-59","source":"Crossref","is-referenced-by-count":1,"title":["Oxygen requirement and surfactant therapy in preterm infants after delivery"],"prefix":"10.1111","volume":"57","author":[{"given":"Mihiro","family":"Toriyama","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"},{"name":"Department of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Ehime Prefectural Center Hospital  Matsuyama Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Motojima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Yamana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Sobajima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatal Medicine Center for Maternal Fetal and Neonatal Medicine Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17189-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00032809"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2006.06.134"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.08-221"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0434"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000143397"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1984"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971127"},{"key":"e_1_2_6_10_1","unstructured":"Neonatal Research Network Database in Japan.RDS by Gestational Age. 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