{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:33:39Z","timestamp":1760549619151},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the relationship between prognosis and the changes in serum\u2010ionized calcium concentration in neonates with hypoxic\u2013ischemic encephalopathy (<jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>) before and during brain hypothermia (<jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples were obtained from 16 <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> neonates who underwent <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content>. All patients underwent developmental testing at 18 months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean serum\u2010ionized calcium concentration in the poor outcome group (developmental quotient [<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>], &lt;80; nine infants) was significantly lower than in the good outcome group (<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content> &gt;80; seven infants), both immediately before and after 6\u2009h of <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content>. Mean serum\u2010ionized calcium concentration significantly decreased in both groups for 6\u2009h, and the lowest adjusted serum\u2010ionized calcium during 6\u2009h of <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> was &lt;1.05\u2009mmol\/L, known as the cut\u2010off value for poor outcome, in 57.1% of the good outcome group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The influx of calcium into cells continues regardless of neurological prognosis during the early phase of <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> might protect some high\u2010risk patients against neurological damage at low adjusted serum\u2010ionized calcium concentration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12438","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T08:11:17Z","timestamp":1412669477000},"page":"64-67","source":"Crossref","is-referenced-by-count":5,"title":["Calcium concentration in hypoxic\u2013ischemic encephalopathy during hypothermia"],"prefix":"10.1111","volume":"57","author":[{"given":"Yutaka","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Neonatology Gifu Prefectural General Medical Center  Gifu Japan"},{"name":"Department of Pediatrics Graduate School of Medicine Gifu University  Gifu Japan"},{"name":"Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ibara","sequence":"additional","affiliation":[{"name":"Perinatal Medical Center Kagoshima City Hospital  Kagoshima 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