{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T15:42:35Z","timestamp":1696088555292},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent advances in biologic therapy have enabled reduction of the progression of destructive arthritis in rheumatoid arthritis. Once destroyed, however, the affected bones and cartilage are not fully repaired. We describe the case of an 8\u2010year\u2010old girl with anti\u2010citrullinated peptide antibody (<jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>)\u2010positive polyarticular juvenile idiopathic arthritis (p\u2010JIA). Destructive arthritis progressed during combination therapy with infliximab, methotrexate, mizoribine and prednisolone. Clinical remission was achieved, however, after switching the biologic agent to tocilizumab, a humanized monoclonal antibody to interleukin\u20106 receptor. Both bone erosion and bone marrow edema on magnetic resonance imaging were repaired in association with restoration of joint spaces. Furthermore, there was no relapse of arthritis on weekly methotrexate alone for 2 years after discontinuation of the tocilizumab. Tocilizumab led to radiological repair of both bone and cartilage destruction and long\u2010term biologics\u2010free remission in a patient with <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>\u2010positive p\u2010JIA, and should be considered for tumor necrosis factor inhibitor\u2010resistant cases.<\/jats:p>","DOI":"10.1111\/ped.12454","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T02:58:05Z","timestamp":1428980285000},"page":"307-310","source":"Crossref","is-referenced-by-count":4,"title":["Radiological improvement by tocilizumab in polyarticular juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"57","author":[{"given":"Yusuke","family":"Tozawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Goryokaku Hospital  Hakodate"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Goryokaku Hospital  Hakodate"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Goryokaku Hospital  Hakodate"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Goryokaku Hospital  Hakodate"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2012.03.008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-29"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204761"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0325-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0481-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201075"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.145359"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204137"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.153023"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.854079"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12454","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:59:28Z","timestamp":1695981568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ped.12454"],"URL":"https:\/\/doi.org\/10.1111\/ped.12454","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}