{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:31:44Z","timestamp":1761895904893},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Of late, there is an increased awareness of the frequent occurrence of hypertension or proteinuria in adults born at low birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied five children born with extremely low birthweight (<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>) who were first diagnosed with proteinuria in a school urinary screening program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>These children were born at 23\u201325 weeks of gestation, and their birthweight was 532\u2013732\u2009g. Proteinuria was identified in all the subjects in a school urinary screening program when they were 6\u201315 years old. Renal biopsy showed diffuse increase in glomerular size, consistent with glomerular hypertrophy. There were no findings of mesangial proliferation or glomerular sclerosis. All the subjects had a marked decrease in proteinuria after angiotensin receptor blocker (<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced number of glomeruli associated with prematurity was speculated to have caused compensatory glomerular hyperfiltration, hypertrophy, and hypertension in children born with <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> when they developed proteinuria. <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> could have been effective for proteinuria by reducing glomerular hypertension. Physicians should be aware of proteinuria in children born with <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> because there is an increasing number of <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> survivors as a result of advances in medical technology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12466","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T05:11:54Z","timestamp":1407215514000},"page":"860-864","source":"Crossref","is-referenced-by-count":13,"title":["Proteinuria and glomerular hypertrophy in extremely low\u2010birthweight children"],"prefix":"10.1111","volume":"56","author":[{"given":"Asako","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Santo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Satomura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"191","article-title":"Oligonephropathy: From a rare childhood disorder to a possible health problem in the adult","volume":"4","author":"Drukker A","year":"2002","journal-title":"Isr. 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