{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:38:10Z","timestamp":1784198290634,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Serum procalcitonin (PCT<\/jats:styled-content>) increases in various respiratory disorders such as acute respiratory distress syndrome. Elevated PCT<\/jats:styled-content> is also observed in healthy neonates. In this study, we investigated whether PCT<\/jats:styled-content> is a good marker of respiratory disorder in neonates.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 155 neonates with or without respiratory disorder, were eligible for the study. PCT<\/jats:styled-content> was measured on electrochemiluminescence immunoassay. Each neonate was allocated to the non\u2010respiratory disorder (control) group (n<\/jats:italic> = 95), or a respiratory disorder group (n<\/jats:italic> = 60). PCT<\/jats:styled-content> was compared between the groups, and association with other markers, including C<\/jats:styled-content>\u2010reactive protein (CRP<\/jats:styled-content>) and white blood cell (WBC<\/jats:styled-content>) count, was analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 60 neonates in the respiratory disorder group, 39, 10, five, one, two, two, and one neonates had transient tachypnea of the newborn, respiratory distress syndrome, air leak syndrome, meconium aspiration syndrome, 18\u2010trisomy, neonatal asphyxia, and congenital diaphragmatic hernia, respectively. Mean PCT<\/jats:styled-content>, CRP<\/jats:styled-content> and WBC<\/jats:styled-content> count in the respiratory disorder group were 9.01\u2009ng\/mL, 0.26\u2009mg\/dL, and 16\u2009100 cells\/\u03bcL, respectively. The area under the curve obtained for PCT<\/jats:styled-content> in distinguishing between the respiratory disorder and control groups was 0.85 (sensitivity, 66.7%; specificity, 93.0%; optimum cut\u2010off, 3.73\u2009ng\/mL), that for CRP<\/jats:styled-content> was 0.72 (sensitivity, 75.0%; specificity, 64.6%; optimum cut\u2010off, 0.14\u2009mg\/dL), and for WBC<\/jats:styled-content> it was 0.44 (sensitivity, 60.0%; specificity, 29.6%; optimum cut\u2010off, 15\u2009000\u2009cells\/\u03bcL).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>PCT<\/jats:styled-content> is more susceptible, as a diagnostic parameter of infection, to the effect of respiratory disturbance than CRP<\/jats:styled-content> and WBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12505","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T03:06:00Z","timestamp":1410836760000},"page":"263-268","source":"Crossref","is-referenced-by-count":18,"title":["Procalcitonin as a marker of respiratory disorder in neonates"],"prefix":"10.1111","volume":"57","author":[{"given":"Fumihiro","family":"Ochi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Perinatal Medical Center and Children's General Medical Center Ehime University Hospital Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Perinatal Medical Center and Children's General Medical Center Ehime University Hospital Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Chisaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomozo","family":"Moritani","sequence":"additional","affiliation":[{"name":"Perinatal Medical Center and Children's General Medical Center Ehime University Hospital Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisamichi","family":"Tauchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.12.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.304"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-7-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701813735"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.085449"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/clinchem\/44.6.1343","article-title":"Increased serum procalcitonin in newborn infants without infection","volume":"44","author":"Sachse C","year":"1998","journal-title":"Clin. 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