{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T07:40:04Z","timestamp":1717918804329},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The older of two siblings began to have spasms and partial seizures at 1 month of age. Head magnetic resonance imaging showed an abnormal area in the left temporo\u2010parieto\u2010occipital region. Interictal electroencephalogram (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) showed a suppression\u2013burst pattern. Adrenocorticotropic hormone stopped the spasms, but the seizures continued. Clonazepam, carbamazepine, zonisamide, and clobazam were ineffective. She underwent focal resection at age 8 months. Postoperatively, the seizures disappeared. Histopathologically, the lesion appeared to be focal cortical dysplasia type<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>a. The younger sibling had spasms from birth. Head magnetic resonance imaging showed left hemi\u2010megalencephaly. Interictal<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>showed a suppression\u2010burst pattern. Phenobarbital, valproic acid, and zonisamide were ineffective. He underwent hemispherotomy at age 2 months and became seizure free. The histopathological features were consistent with those of hemi\u2010megalencephaly. The siblings\u2019<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>and clinical courses had some similarities. These siblings\u2019 conditions may have the same genetic background.<\/jats:p>","DOI":"10.1111\/ped.12509","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T17:07:32Z","timestamp":1432746452000},"page":"472-475","source":"Crossref","is-referenced-by-count":0,"title":["Two siblings with cortical dysplasia: Clinico\u2010electroencephalographic features"],"prefix":"10.1111","volume":"57","author":[{"given":"Tatsuya","family":"Fukasawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Anjo Kosei Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Anjo Kosei Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Negoro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Anjo Kosei Hospital Aichi Japan"},{"name":"Department of 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