{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:46:35Z","timestamp":1788468395121,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anastomotic stricture is the main complication after esophageal atresia (<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>) repair. In this study, we assessed the efficacy of long\u2010term prophylactic <jats:styled-content style=\"fixed-case\">H2<\/jats:styled-content> blocker treatment in preventing stricture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven patients who had undergone primary repair for <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content> (Gross type <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) were reviewed retrospectively. The patients were analyzed in two groups: the <jats:styled-content style=\"fixed-case\">H2<\/jats:styled-content> blocker group (<jats:italic>n<\/jats:italic> = 13), in which the patients were treated with prophylactic <jats:styled-content style=\"fixed-case\">H2<\/jats:styled-content> blocker; and the control group (<jats:italic>n<\/jats:italic> = 14), in which they were not. To assess anastomotic stricture, contrast esophagography was performed and the number of patients who required balloon dilatation was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients (18.5%) required postoperative balloon dilatation within 1\u2009year of primary repair. There was no difference in dilatation rate between the two groups. In the <jats:styled-content style=\"fixed-case\">H2<\/jats:styled-content> blocker group, however, anastomotic stricture improved significantly in the late postoperative period relative to that in the early postoperative period. In contrast, in the control group, anastomotic stricture did not improve after a long postoperative period. The incidence of gastroesophageal reflux was 55.6%. Postoperative gastroesophageal reflux was a predisposing factor for balloon dilatation in the control group, but not in the <jats:styled-content style=\"fixed-case\">H2<\/jats:styled-content> blocker group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term treatment with prophylactic <jats:styled-content style=\"fixed-case\">H2<\/jats:styled-content> blocker may prevent anastomotic stricture caused by gastroesophageal reflux in the late postoperative period after <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content> repair.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12529","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T07:37:54Z","timestamp":1414481874000},"page":"461-464","source":"Crossref","is-referenced-by-count":14,"title":["Prophylactic effect of <scp>H2<\/scp> blocker for anastomotic stricture after esophageal atresia repair"],"prefix":"10.1111","volume":"57","author":[{"given":"Naruhiko","family":"Murase","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenitiro","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12051"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1347917"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.10.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90561-M"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1308698"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106149"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/64412147"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.11.009"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050252"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9019"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12529","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.12529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:00:02Z","timestamp":1696168802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/ped.12529"],"URL":"https:\/\/doi.org\/10.1111\/ped.12529","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]}}}