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From 2010 to 2013, we (members of the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese Research Group on Congenital Insensitivity to Pain) carried out research on <jats:styled-content style=\"fixed-case\">HSAN<\/jats:styled-content> types <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>. Research by this group included epidemiological data, examination of clinical findings, solutions of disease etiology, investigation of complications and development of their management. Complications were categorized into musculoskeletal complications, oral\/dental complications, dermal complications, ocular complications, complications resulting from impaired thermal control, anesthetic considerations, other complications possibly related to autonomic dysfunction, and abnormal mental development and behavior. Treatment and care for patients with <jats:styled-content style=\"fixed-case\">HSAN<\/jats:styled-content> types <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> require a wide range of knowledge and experience, and a multidisciplinary team approach. Therefore, we produced the \u201cGuideline of Total Management and Care for Congenital Insensitivity to Pain (<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>er.1)\u201d in 2012, to provide information for medical specialists based on our knowledge and experience. This guideline includes medical issues, as well as descriptions of social participation and welfare. This review outlines the situation of <jats:styled-content style=\"fixed-case\">HSAN<\/jats:styled-content> types <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan, and the recommendations of treatment and care for patients, mostly based on research conducted by the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese Research Group.<\/jats:p>","DOI":"10.1111\/ped.12538","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T07:09:58Z","timestamp":1416899398000},"page":"30-36","source":"Crossref","is-referenced-by-count":35,"title":["Hereditary sensory and autonomic neuropathy types <scp>IV<\/scp> and <scp>V<\/scp> in <scp>J<\/scp>apan"],"prefix":"10.1111","volume":"57","author":[{"given":"Nobuhiko","family":"Haga","sequence":"first","affiliation":[{"name":"Department of 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