{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T04:35:17Z","timestamp":1719117317946},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:00:00Z","timestamp":1423267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitochondrial renal disease is one of the important causes of end\u2010stage renal disease in children and its incidence may be underestimated. We here describe the case of a 13\u2010year\u2010old girl who was diagnosed with mitochondrial disease (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) accompanied by <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> nephropathy (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>). She presented with persistent proteinuria, short stature, and hearing defect, and her younger sister had the same symptoms. Renal biopsy indicated mild focal segmental mesangial proliferation with dominant mesangial <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> deposition on immunofluorescence. Electron microscopy showed marked proliferation of abnormal mitochondria in the proximal tubular cells. Enzyme activity of the mitochondrial respiratory chain complex <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in cultured skin fibroblasts was significantly decreased. This case indicated the possible co\u2010occurrence of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. Underlying <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> should be considered in patients with urine abnormalities, especially in those with multiple organ involvement.<\/jats:p>","DOI":"10.1111\/ped.12540","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T06:07:01Z","timestamp":1423289221000},"source":"Crossref","is-referenced-by-count":7,"title":["<scp>I<\/scp>g<scp>A<\/scp> nephropathy in a girl with mitochondrial disease"],"prefix":"10.1111","volume":"57","author":[{"given":"Masashi","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology and Nephrology Kyoto Prefectural University of Medicine Graduate School of Medical Science  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto Prefectural University of Medicine Graduate School of Medical Science  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto Second Red Cross Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hamaoka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Nephrology Kyoto Prefectural University of Medicine Graduate School of Medical Science  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1926-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2362-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00571.2013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1814-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.01.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1127-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.6s.2.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg170"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12540","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:59:01Z","timestamp":1695981541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,7]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ped.12540"],"URL":"https:\/\/doi.org\/10.1111\/ped.12540","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,7]]}}}