{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T10:27:13Z","timestamp":1744194433719},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to clarify how extracorporeal membrane oxygenation (ECMO<\/jats:styled-content>) is used to treat congenital diaphragmatic hernia (CDH<\/jats:styled-content>) in J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec>Methods<\/jats:title>We completed a nationwide survey of CDH<\/jats:styled-content> involving 614 infants. The subjects included 43 patients who underwent ECMO<\/jats:styled-content>. We compared the clinical data of the patients who did and did not survive \u226590 days, and analyzed the 24\u2009h blood gas data in isolated CDH<\/jats:styled-content> cases in both groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 43 CDH<\/jats:styled-content> patients, non\u2010isolated CDH<\/jats:styled-content> associated with other life\u2010threatening or chromosomal anomalies was diagnosed in six patients. Only one of these six patients was able to discontinue ECMO<\/jats:styled-content> and survived, and the other five died shortly after birth. The other 37 patients all had isolated CDH<\/jats:styled-content>. The reason for initiating ECMO<\/jats:styled-content> in 31 of these patients was persistent pulmonary hypertension of the newborn (PPHN<\/jats:styled-content>). In the 37 patients with isolated CDH<\/jats:styled-content>, ECMO<\/jats:styled-content> was initiated within 24\u2009h after birth. Sixteen patients (37%) survived \u226590 days, and intact discharge was possible in eight cases. Among the isolated CDH<\/jats:styled-content> patients, on ROC<\/jats:styled-content> analysis of the lowest oxygenation index (OI<\/jats:styled-content>) to predict 90 day survival, the cut\u2010off was 15.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>ECMO<\/jats:styled-content> is used to treat PPHN<\/jats:styled-content> starting from an early period after birth, but the mortality and morbidity are not favorable. For lowest OI<\/jats:styled-content>, the index used to predict survival following ECMO<\/jats:styled-content>, the cut\u2010off was 15.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12554","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T08:00:39Z","timestamp":1418112039000},"page":"682-686","source":"Crossref","is-referenced-by-count":6,"title":["Extracorporeal membrane oxygenation for congenital diaphragmatic hernia in J<\/scp>apan"],"prefix":"10.1111","volume":"57","author":[{"given":"Noboru","family":"Inamura","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroomi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kanamori","sequence":"additional","affiliation":[{"name":"Department of General Surgery National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Osaka University Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Neonatology National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"69","article-title":"Management of a newborn with congenital diaphragmatic hernia","volume":"24","author":"Puri P","year":"1989","journal-title":"Mod. 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