{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:03:35Z","timestamp":1763705015349},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a 19\u2010year\u2010old woman with a highly malignant intracranial germ cell tumor (<jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>) that developed 14 years after treatment for neurohypophyseal germinoma. Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) showed a large neurohypophyseal mass and a synchronous lesion in the pineal region. Plasma \u03b1\u2010fetoprotein was elevated to 3038\u2009ng\/mL. Although the tumor shrank and tumor marker levels normalized after chemotherapy and craniospinal irradiation, treatment was switched to oral etoposide for the residual tumor because of adverse events. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> after oral etoposide introduction showed additional tumor shrinkage for 27 months after the onset of the second tumor. To the best of our knowledge, this is the longest interval between germinoma onset and the development of highly malignant recurrent <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content> to be reported in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nglish\u2010language literature. Oral etoposide prevented regrowth of the <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>, which has a poor prognosis, and decreased the size of the residual tumor.<\/jats:p>","DOI":"10.1111\/ped.12559","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T04:23:25Z","timestamp":1424838205000},"page":"483-486","source":"Crossref","is-referenced-by-count":2,"title":["Malignant transformation of germinoma 14 years after onset: Favorable efficacy of oral etoposide"],"prefix":"10.1111","volume":"57","author":[{"given":"Kohei","family":"Fukuoka","sequence":"first","affiliation":[{"name":"Division of Pediatric Neuro\u2010Oncology Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neuro\u2010Oncology Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonari","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neuro\u2010Oncology Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Shirahata","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Fujimaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Saitama Medical University Hospital  Moroyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Matsutani","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology\/Neurosurgery Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"198","volume-title":"WHO Classification of Tumors of the Central Nervous System","author":"Rosenblum MK","year":"2007"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.3.0446"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.9.PEDS12151"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01194796"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840901)54:5<903::AID-CNCR2820540525>3.0.CO;2-D"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-002-0951-4"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.31.1012"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.12.2008.1351"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.6.1922"},{"key":"e_1_2_4_11_1","first-page":"36","article-title":"Phase II study of daily oral etoposide in refractory germ cell tumors","volume":"17","author":"Miller JC","year":"1990","journal-title":"Semin. 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