{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:54:33Z","timestamp":1777121673417,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemophagocytic lymphohistiocytosis (<jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>) is a life\u2010threatening disorder of immune regulation. <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> consists of two forms: familial and acquired, the latter which occurs in association with infection, malignancy, rheumatic disease and acquired immune deficiency. Herein, we report a case of acquired <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> in a child who had received allogeneic hematopoietic stem cell transplantation for familial <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> with <jats:italic><jats:styled-content style=\"fixed-case\">UNC13D<\/jats:styled-content><\/jats:italic> mutation. Based on microbiology, only rotavirus was identified as a possible organism triggering <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>. The patient's fulminant clinical course included acute respiratory failure, a sepsis\u2010like pattern, disseminated intravascular coagulopathy, and rhabdomyolysis, leading to multiorgan failure and death from septic shock.<\/jats:p>","DOI":"10.1111\/ped.12567","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T04:23:40Z","timestamp":1424838220000},"source":"Crossref","is-referenced-by-count":7,"title":["Rotavirus\u2010associated hemophagocytic lymphohistiocytosis (<scp>HLH<\/scp>) after hematopoietic stem cell transplantation for familial <scp>HLH<\/scp>"],"prefix":"10.1111","volume":"57","author":[{"given":"Meerim","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics Chungbuk National University College of Medicine  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Ju","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University College of Medicine  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Il","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University College of Medicine  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul St Mary's Hospital Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nack\u2010Gyun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul St Mary's Hospital Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul St Mary's Hospital Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-041610-134208"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0258-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.82"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.605"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051033"},{"key":"e_1_2_5_7_1","first-page":"153","article-title":"Hemophagocytic lymphohistiocytosis in a child with rotavirus encephalopathy","volume":"14","author":"Enoki H","year":"2008","journal-title":"Neurol. 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