{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:16:40Z","timestamp":1780525000031,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine whether electrocardiographic signs correlate with hemodynamics and the magnitude of the intracardiac shunt in children with ostium secundum atrial septal defects (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients (median age, 6 years 4 months; 54 girls) underwent cardiac catheterization between <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 1980 and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2010. We retrospectively investigated the relationship between electrocardiographic signs and the pulmonary\/systemic blood flow ratio (<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s) in these patients. We also compared 63 postoperative electrocardiograms with those recorded before surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s ratio of the 100 patients was 2.46 \u00b1 0.81 (range, 1.1\u20135.0). The <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s ratio in patients with and without right bundle branch block (<jats:styled-content style=\"fixed-case\">RBBB<\/jats:styled-content>) was 2.57 \u00b1 0.82 (<jats:italic>n<\/jats:italic> = 73) and 2.15 \u00b1 0.72 (<jats:italic>n<\/jats:italic> = 27), respectively (<jats:italic>P<\/jats:italic> = 0.016). The <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s ratio in patients with and without isolated negative <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010wave was 2.85 \u00b1 0.87 (<jats:italic>n<\/jats:italic> = 38) and 2.22 \u00b1 0.68 (<jats:italic>n<\/jats:italic> = 62), respectively (<jats:italic>P<\/jats:italic> = 0.0003). None of the patients with low <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s ratio (<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s ratio \u2264 1.5) had both <jats:styled-content style=\"fixed-case\">RBBB<\/jats:styled-content> and isolated negative <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010wave. The prevalence of these two signs decreased from 73.0% (<jats:italic>n<\/jats:italic> = 46) and 36.5% (<jats:italic>n<\/jats:italic> = 23) to 15.9% (<jats:italic>n<\/jats:italic> = 10) and 15.9% (<jats:italic>n<\/jats:italic> = 10) after surgical repair, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RBBB<\/jats:styled-content> and isolated negative <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010wave in the precordial leads are well correlated with high <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>p\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>s ratio in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12569","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:03:42Z","timestamp":1418979822000},"page":"535-540","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between electrocardiographic signs and shunt volume in atrial septal defect"],"prefix":"10.1111","volume":"57","author":[{"given":"Junpei","family":"Somura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Ukiami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02083294"},{"key":"e_1_2_6_3_1","first-page":"338","article-title":"Effectiveness of the Amplatzer device for transcatheter closure of an ostium secundum atrial septal defect","volume":"88","author":"Cardoso CO","year":"2007","journal-title":"Arq. 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