{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:10:09Z","timestamp":1773850209129,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Chronic active Epstein\u2013Barr virus (EBV<\/jats:styled-content>) infection (CAEBV<\/jats:styled-content>), characterized by persistent infectious mononucleosis\u2010like symptoms, can lead to cardiovascular complications including coronary artery aneurysm or myocarditis. Here, we present the case of an 11\u2010year\u2010old boy with pulmonary arterial hypertension (PAH<\/jats:styled-content>) and junctional ectopic tachycardia associated with CAEBV<\/jats:styled-content>. The patient did not have any major symptoms attributed to CAEBV<\/jats:styled-content>, such as fever, lymphadenopathy or splenomegaly when the PAH<\/jats:styled-content> developed. Mild liver dysfunction was found at the first examination, and it persisted. Two years after the PAH<\/jats:styled-content> symptoms appeared, CAEBV<\/jats:styled-content> was evident, based on deteriorated liver function, hepatosplenomegaly, and coronary artery aneurysms. CAEBV<\/jats:styled-content> should be considered as a cause of secondary PAH<\/jats:styled-content>, particularly when liver dysfunction coexists.<\/jats:p>","DOI":"10.1111\/ped.12578","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T03:50:02Z","timestamp":1427341802000},"page":"731-734","source":"Crossref","is-referenced-by-count":13,"title":["Pulmonary arterial hypertension associated with chronic active Epstein\u2013Barr virus infection"],"prefix":"10.1111","volume":"57","author":[{"given":"Yutaka","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Takeda General Hospital Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Momoi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Akaihata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takeda General Hospital Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takeda General Hospital Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mitomo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisei","family":"Endoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.505"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.2.280"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/333455a0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/367988"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13547.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9343-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4143"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200301000-00018"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03584.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12578","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:50:08Z","timestamp":1695984608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ped.12578"],"URL":"https:\/\/doi.org\/10.1111\/ped.12578","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}