{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:32:55Z","timestamp":1776299575922,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) in infants is among the most common reason for physician consultation worldwide. A traditional Japanese medicine, rikkunshito (<jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content>), is effective for <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> in adult and pediatric patients. The aim of this study was to evaluate the efficacy and safety of <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> in infants with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four infants were referred to between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2004 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012 for evaluation and treatment of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. All infants had failure to thrive. We excluded nine patients with cow's milk protein allergy, neurological impairment or surgical indications. We retrospectively reviewed the clinical records of 45 infants with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. Twenty\u2010nine infants were treated with <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\u201043; 0.3\u2009g\/kg\/day; <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> group), and 16 infants were treated with mosapride citrate at 0.5\u2009mg\/kg\/day (mosapride group). The primary endpoint was <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content>\u2010induced relief of clinical symptoms and bodyweight gain in infants with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3 months of treatment, the frequency of vomiting per day was significantly lower in the <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> group than in the mosapride group (<jats:italic>P<\/jats:italic> = 0.0146) and the weight <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>\u2010score was significantly higher in the <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> group than in the mosapride group (<jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> group, \u22122.5 \u00b1 1.5 vs mosapride group, \u22125.0 \u00b1 2.0; <jats:italic>P<\/jats:italic> = 0.0386). No adverse effects were noted in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> may be safe and effective for relief of <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> symptoms and for bodyweight gain in infants with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12582","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T08:10:53Z","timestamp":1420531853000},"page":"673-676","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of the <scp>J<\/scp>apanese herbal medicine rikkunshito in infants with gastroesophageal reflux disease"],"prefix":"10.1111","volume":"57","author":[{"given":"Kohei","family":"Otake","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhki","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyuki","family":"Takamura","sequence":"additional","affiliation":[{"name":"Kampo Medicine Outpatient Department Mie University Hospital  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikihiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200100002-00001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.10.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.31.4.229"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01290.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-007-1986-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0488-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2453-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-014-3565-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2004.00424.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04517.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200310000-00009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2289-z"},{"key":"e_1_2_6_14_1","first-page":"211","article-title":"Liu\u2010Jun\u2010Zi\u2010Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs","volume":"25","author":"Hayakawa T","year":"1999","journal-title":"Drugs Exp. 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