{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:17:11Z","timestamp":1784715431613,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labour and Welfare of Japan","award":["H25-nanchi-ippan-015"],"award-info":[{"award-number":["H25-nanchi-ippan-015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Surgical intestinal disorders, such as necrotizing enterocolitis (NEC<\/jats:styled-content>), focal intestinal perforation (FIP<\/jats:styled-content>), and meconium\u2010related ileus (MRI<\/jats:styled-content>), are serious morbidities in very low\u2010birthweight infants (VLBWI<\/jats:styled-content>). The aim of this study was to compare the composite outcomes of death or neurodevelopmental impairment (NDI<\/jats:styled-content>) in VLBWI<\/jats:styled-content> with surgical intestinal disorders and assess independent risk factors for death and NDI<\/jats:styled-content> at 18\u2009months of corrected age.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective matched\u2010cohort study was conducted at 11 institutes. We included VLBWI<\/jats:styled-content> who had undergone laparotomy for NEC<\/jats:styled-content>, FIP<\/jats:styled-content>, and MRI<\/jats:styled-content>. Two control subjects were chosen for every surgical patient and matched for gestational age and birthweight to form the comparison group. Death and neurodevelopmental outcome at 18\u2009months of corrected age were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>The number of infants in the NEC<\/jats:styled-content>, FIP<\/jats:styled-content>, MRI<\/jats:styled-content>, and control groups was 44, 47, 42, and 261, respectively. In\u2010hospital mortality was higher in infants with NEC<\/jats:styled-content> and MRI<\/jats:styled-content> relative to those in the control group (P<\/jats:italic> < 0.001). The incidence rate for NDI<\/jats:styled-content> at 18\u2009months of corrected age was higher in infants with MRI<\/jats:styled-content> relative to those in the control group (P<\/jats:italic> = 0.021). On logistic regression analysis, low gestational age, male sex, small for gestational age, intraventricular hemorrhage, and MRI<\/jats:styled-content> were associated with increased risk of death or NDI<\/jats:styled-content> at 18\u2009months of corrected age.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>NEC<\/jats:styled-content> and MRI<\/jats:styled-content> were associated with in\u2010hospital mortality, and MRI<\/jats:styled-content> was associated with NDI<\/jats:styled-content> or death at 18\u2009months of corrected age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12594","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T09:17:29Z","timestamp":1422609449000},"page":"633-638","source":"Crossref","is-referenced-by-count":16,"title":["Outcome in VLBW<\/scp> infants with surgical intestinal disorder at 18\u2009months of corrected age"],"prefix":"10.1111","volume":"57","author":[{"given":"Masahiro","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Division of Neonatology, Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medical Sciences, Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Urushihara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Shizuoka Children's Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hyogo Prefectural Kobe Children's Hospital Kobe 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Department of Neonatology Japanese Red Cross Nagoya First Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Anjo Kosei Hospital Anjo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Ohfuji","sequence":"additional","affiliation":[{"name":"Department of Public Health Osaka City University Faculty of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroomi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka University Graduate School of Medicine Suita Japan"},{"name":"Department of Pediatric Surgery Hyogo College of Medicine Nishinomiya 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