{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:48:55Z","timestamp":1764305335439},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reintroduction of measles\u2013rubella combined (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) vaccination to <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan raised concerns about adverse events as well as immunogenicity related to booster immunization in subjects with naturally acquired immunity to measles or rubella.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The time course of reactogenicity and antibody responses in recipients with pre\u2010existing immunity to measles through natural infection was observed. Eighteen children aged 80\u2013104\u2009months received <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> booster vaccination; 16 of them had had previous rubella vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were virtually no clinical reactions related to booster vaccination, and a highly significant antibody response to rubella antigen, whereas the antibody rise to measles was statistically significant but poor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vaccination of individuals already immune is not harmful. Booster immunization to rubella for Japanese children is vitally important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12596","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T09:17:49Z","timestamp":1422609469000},"page":"597-602","source":"Crossref","is-referenced-by-count":1,"title":["Reactogenicity and immunogenicity of measles\u2013rubella combined vaccine in school\u2010entry\u2010aged subjects with naturally acquired measles immunity"],"prefix":"10.1111","volume":"57","author":[{"given":"Takuji","family":"Kumagai","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Infectious Diseases Society of Sapporo Kumagai Pediatric Clinic  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Mie National Hospital  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Infection I Kitasato Institute for Life Sciences  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Nagata","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Infectious Diseases Society of Sapporo Hiraoka\u2010Kohen Pediatric Clinic  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Infection I Kitasato Institute for Life Sciences  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.01.001"},{"key":"e_1_2_6_3_1","first-page":"9","volume-title":"Red Book: 2006 Report of the Committee on Infectious Diseases","author":"American Academy of Pediatrics","year":"2006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.e62"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(91)90053-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(94)90049-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(97)00174-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00081-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00207-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10390"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00397-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(94)90009-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(94)00021-E"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00143-O"},{"key":"e_1_2_6_15_1","first-page":"R26","article-title":"The epidemiology of rubella in England and Wales before and after the 1994 measles and rubella vaccination campaign: Fourth joint report from the PHLS and the National Congenital Rubella Surveillance Programme","volume":"7","author":"Miller E","year":"1997","journal-title":"Commun. 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