{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:35:27Z","timestamp":1788820527306,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brucellosis is the most common zoonotic disease worldwide and remains an important human disease especially in developing countries. The aim of the present study was to evaluate clinical manifestations and laboratory findings of childhood brucellosis in<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>an province of<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>astern<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkey. To our knowledge, this is the largest series of childhood brucellosis reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, 496 children with brucellosis were assessed for the clinical manifestations and laboratory findings from<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2009 through<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2013. The diagnosis of brucellosis was based on clinical findings and a standard tube agglutination test (titer \u22651:160). Data were analyzed using<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>initab version 16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 496 children (boys, 60.5%) with a mean age of 10.0\u2009\u00b1\u20093.95 years (range, 1\u201316 years). The most frequent clinical symptoms were arthralgia (46.2%), fever (32.1%), and abdominal pain (17.1%) and the most common clinical signs were peripheral arthritis (10.1%), splenomegaly (2.2%) and hepatomegaly (1.8%). The most contagious seasons were summer and autumn (63.3%). Elevated lactate dehydrogenase and<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein and erythrocyte sedimentation rate were reported in 63.1%, 58.7%, and 55.2% of the patients, respectively. Anemia (20.4%), thrombocytopenia (15.5%), and leukopenia (12.1%) were the most common hematologic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brucellosis remains a serious public health problem in<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkey. The clinical and laboratory characteristics of childhood brucellosis have been described in order to assist clinicians in diagnosing and monitoring the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12598","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T13:26:47Z","timestamp":1423834007000},"page":"586-589","source":"Crossref","is-referenced-by-count":23,"title":["Clinical manifestations and laboratory findings of 496 children with brucellosis in<scp>V<\/scp>an,<scp>T<\/scp>urkey"],"prefix":"10.1111","volume":"57","author":[{"given":"Mehmet","family":"Parlak","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Akbayram","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat","family":"\u00d6zl\u00fck","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Tuba","family":"Akbayram","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"\u00d6ner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease Yuzuncu Yil University Faculty of Medicine Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.2.283"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609356426"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6565"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2005003"},{"key":"e_1_2_6_6_1","first-page":"207","article-title":"Human brucellosis: A clinical infectious disease with persistent diagnostic challenges","volume":"12","author":"Araj GF","year":"1999","journal-title":"Clin. 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