{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T06:03:33Z","timestamp":1745906613365},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are few reports on successful high\u2010dose spironolactone treatment of refractory protein\u2010losing enteropathy (<jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>) caused by Fontan procedure. We report successful diuretics treatment with spironolactone and furosemide at standard dose, of refractory <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> in a patient with <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>oonan syndrome and repaired congenital heart disease. This is the first successful application of diuretics treatment in a patient with refractory <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> without Fontan procedure. This case illustrates that diuretics treatment can be the first\u2010line treatment of <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> regardless of the causative physiology, and can be effective in refractory <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>oonan syndrome.<\/jats:p>","DOI":"10.1111\/ped.12603","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T02:58:05Z","timestamp":1428980285000},"source":"Crossref","is-referenced-by-count":4,"title":["Successful diuretics treatment of protein\u2010losing enteropathy in <scp>N<\/scp>oonan syndrome"],"prefix":"10.1111","volume":"57","author":[{"given":"Tatsuki","family":"Mizuochi","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiro","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironaga","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motofumi","family":"Iemura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Tanikawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyojiro","family":"Matsuishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.561"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3207"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00518.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00135-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2009.00320.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.03.039"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05225.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.12417"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:59:20Z","timestamp":1695981560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ped.12603"],"URL":"https:\/\/doi.org\/10.1111\/ped.12603","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}