{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:15:13Z","timestamp":1792192513297,"version":"4.4.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages. Recently, we encountered the case of a 3\u2010year\u2010old Japanese girl who suffered from severe intrinsic acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) after therapeutic doses of acetaminophen for a fever due to viral infection. Renal biopsy indicated severe acute tubular necrosis with a significant striped interstitial fibrosis and mild interstitial inflammation. Unfortunately, she developed chronic kidney disease thereafter. This is the youngest case of biopsy\u2010proven severe intrinsic <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> associated with therapeutic doses of acetaminophen. Acetaminophen, even if administered at therapeutic dosages, may be dangerous in selected children, especially with possible pre\u2010existing volume depletion.<\/jats:p>","DOI":"10.1111\/ped.12607","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T02:58:05Z","timestamp":1428980285000},"source":"Crossref","is-referenced-by-count":8,"title":["Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen"],"prefix":"10.1111","volume":"57","author":[{"given":"Tatsuya","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shojiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Tsuruga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hirono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Joh","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"},{"name":"Department of School Health Science Faculty of Education Hirosaki University  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.1.190"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-37-17"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03160941"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2239-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31819e38d4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01209.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1502"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1997.tb03671.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02990.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:59:22Z","timestamp":1695981562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ped.12607"],"URL":"https:\/\/doi.org\/10.1111\/ped.12607","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}