{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:29:53Z","timestamp":1751329793379},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diffuse alveolar hemorrhage (<jats:styled-content style=\"fixed-case\">DAH<\/jats:styled-content>) is a rare disease characterized by dyspnea, cough, hemoptysis, and new alveolar infiltrates. Among the various underlying disorders, vasculitis is believed to play a significant role in the pathogenesis of <jats:styled-content style=\"fixed-case\">DAH<\/jats:styled-content>. Here we report the first case of a patient with <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own syndrome who developed <jats:styled-content style=\"fixed-case\">DAH<\/jats:styled-content> secondary to anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis. This case highlights the significance of vasculitis as well as pulmonary hypoplasia and vulnerability associated with <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own syndrome in the development of <jats:styled-content style=\"fixed-case\">DAH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ped.12612","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T02:58:05Z","timestamp":1428980285000},"source":"Crossref","is-referenced-by-count":2,"title":["Diffuse alveolar hemorrhage secondary to <scp>ANCA<\/scp>\u2010associated vasculitis in a patient with Down syndrome"],"prefix":"10.1111","volume":"57","author":[{"given":"Ikumi","family":"Hori","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Nakaseko","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunology Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michi","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayasu","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunology Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.75.4.258"},{"key":"e_1_2_5_3_1","first-page":"58","article-title":"Idiopathic pulmonary haemosiderosis in a child with Down's syndrome: Case report and review of the literature","volume":"29","author":"Aceti A","year":"2012","journal-title":"Sarcoidosis Vasc. 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