{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:01:35Z","timestamp":1792587695625,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection\u2010associated hemophagocytic syndrome (<jats:styled-content style=\"fixed-case\">IAHS<\/jats:styled-content>), a secondary form of hemophagocytic lymphohistiocytosis (<jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>), has been found following several types of infections and can be fatal. We report herein a case of <jats:styled-content style=\"fixed-case\">IAHS<\/jats:styled-content> following dengue infection in a 14\u2010year\u2010old patient with underlying \u03b1\u2010thalassemia syndrome (non\u2010deletional <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b Constant Spring disease). He developed prolonged fever, thrombocytopenia, and progressive splenomegaly. Further investigations indicated hyperferritinemia, and increased reactive histiocytes with hemophagocytic activity in the bone marrow. He responded promptly to dexamethasone and i.v. immune globulin. Physicians should be aware of this condition, especially in countries where both dengue hemorrhagic fever and thalassemia are prevalent. The fatal outcome of <jats:styled-content style=\"fixed-case\">IAHS<\/jats:styled-content> can be prevented with prompt appropriate treatment.<\/jats:p>","DOI":"10.1111\/ped.12617","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T12:00:51Z","timestamp":1432296051000},"page":"763-765","source":"Crossref","is-referenced-by-count":5,"title":["Hemophagocytic lymphohistiocytosis following dengue hemorrhagic fever in <scp>H<\/scp>b <scp>H<\/scp>\/<scp>H<\/scp>b Constant Spring patient"],"prefix":"10.1111","volume":"57","author":[{"given":"Kamon","family":"Phuakpet","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleebsabai","family":"Sanpakit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassawee","family":"Vathana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayamon","family":"Takpradit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulkanya","family":"Chokephaibulkit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vip","family":"Viprakasit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"issue":"2","key":"e_1_2_4_3_1","first-page":"S530","article-title":"Secondary hemophagocytic lymphohistiocytosis in children: An analysis of etiology and outcome","volume":"85","author":"Veerakul G","year":"2002","journal-title":"J. Med. Assoc. Thai."},{"key":"e_1_2_4_4_1","volume-title":"Comprehensive Guideline for Prevention and Control of Dengue and Dengue Haemorrhagic Fever","author":"Regional Office for South\u2010East Asia","year":"2011"},{"key":"e_1_2_4_5_1","first-page":"329","article-title":"Alpha\u2010thalassaemia: From clinical and molecular diagnosis to bedside management","volume":"7","author":"Viprakasit V","year":"2013","journal-title":"Hematol. Educ."},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/2046905512Y.0000000020"},{"issue":"2","key":"e_1_2_4_7_1","first-page":"S522","article-title":"Effect of red blood cell glucose\u20106\u2010phosphate dehydrogenase deficiency on patients with dengue hemorrhagic fever","volume":"85","author":"Tanphaichitr VS","year":"2002","journal-title":"J. Med. Assoc. Thai."},{"issue":"8","key":"e_1_2_4_8_1","first-page":"S80","article-title":"Dengue hemorrhagic fever in patients with thalassemia","volume":"88","author":"Pongtanakul B","year":"2005","journal-title":"J. Med. Assoc. Thai."},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2011.652667"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.06.005"},{"issue":"17","key":"e_1_2_4_11_1","first-page":"230","article-title":"Reactive macrophage activation syndrome: A simple screening strategy and its potential in early treatment initiation","volume":"132","author":"Emmenegger U","year":"2002","journal-title":"Swiss Med. Wkly"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:50:32Z","timestamp":1695984632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,22]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ped.12617"],"URL":"https:\/\/doi.org\/10.1111\/ped.12617","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,22]]}}}