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These infants were healthy before inoculation, and their detailed immunological profiles, including <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell and neutrophil levels, were within normal range. Most reported <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> cases involve impaired immunity, such as children with chronic granulomatous disease, severe combined immunodeficiency, or human immunodeficiency virus infections. Because of their immature immune systems, <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccination can be hazardous even in early infants without immune abnormalities. Hence, we advise caution when administering <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccines to early infants.<\/jats:p>","DOI":"10.1111\/ped.12623","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T05:32:51Z","timestamp":1433482371000},"page":"750-753","source":"Crossref","is-referenced-by-count":3,"title":["Idiopathic disseminated bacillus <scp>C<\/scp>almette\u2013<scp>G<\/scp>uerin infection in three infants"],"prefix":"10.1111","volume":"57","author":[{"given":"Jun","family":"Kido","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kumamoto Regional Medical Center  Kumamoto Chiba Japan"},{"name":"Department of Pediatrics Graduate School of Medical Sciences Kumamoto University  Kumamoto Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Kumamoto Medical Center  Kumamoto Chiba Japan"},{"name":"Division of Pediatrics Department of Reproductive and Developmental Medicine Faculty of Medicine University of Miyazaki  Miyazaki Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Technology Development Kazusa DNA Research Institute  Kisarazu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Pediatric Medicine Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Yanai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kumamoto Regional Medical Center  Kumamoto Chiba Japan"},{"name":"Vaccination Center of Kumamoto Prefecture  Kumamoto Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"93","article-title":"Quality control of BCG vaccine by WHO: A review of factors that may influence vaccine effectiveness and safety","volume":"68","author":"Milstien JB","year":"1990","journal-title":"Bull. 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