{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:18:19Z","timestamp":1790169499756,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasingly, food allergy associated with tacrolimus after pediatric living\u2010donor liver transplantation (LT) has been reported. Tacrolimus prevents the activation of T cells by blocking calcineurin, thus producing an immunosuppressive effect, but tacrolimus induces an imbalance in T\u2010helper type 1 (Th1) and Th2 cells in the food allergy process. This report describes a case of tacrolimus\u2010associated food allergy after pediatric living\u2010donor LT. The patient was a 7\u2010year\u2010old Japanese girl who had undergone living\u2010donor LT at 12\u2009months of age, and whom we first saw in the clinic at age 18\u2009months. She received immunosuppressive therapy by tacrolimus after transplantation. Atopic dermatitis developed in post\u2010transplant month 18. Stridor, facial edema, lip swelling, and skin erythema after consuming tempura udon containing wheat occurred in post\u2010transplant month 39, and she was subsequently diagnosed with anaphylactic shock. Eosinophilic leukocyte and serum immunoglobulin (Ig)E increased, and specific IgE was positive for some food allergens. Pharmacotherapy was therefore changed from tacrolimus to cyclosporine A, after which eosinophilic leukocyte and serum IgE decreased and atopic dermatitis improved.<\/jats:p>","DOI":"10.1111\/ped.12721","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T03:32:39Z","timestamp":1446780759000},"page":"1205-1207","source":"Crossref","is-referenced-by-count":11,"title":["Management of tacrolimus\u2010associated food allergy after liver transplantation"],"prefix":"10.1111","volume":"57","author":[{"given":"Naho","family":"Obayashi","sequence":"first","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Yokokura","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakayuki","family":"Naritaka","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sugo","sequence":"additional","affiliation":[{"name":"Hepatobiliary\u2010Pancreatic Surgery Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Hepatobiliary\u2010Pancreatic Surgery Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00867.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2002-y"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01114.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00474.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00883.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00542.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00563.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v3.i3.30"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00538.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1094"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12440"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:34:05Z","timestamp":1696034045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/ped.12721"],"URL":"https:\/\/doi.org\/10.1111\/ped.12721","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]}}}