{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:45:23Z","timestamp":1694756723426},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)\u2010negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical course, but CCA in pediatric CML patients are rarely reported. We herein report the case of an 8\u2010year\u2010old boy from the onset of CML. Although he had relapse after unrelated bone marrow transplantation when 9\u2009years old, he has since been in complete molecular response on imatinib mesylate treatment. Surprisingly, various CCA have been observed in this patient, including several reciprocal chromosomal translocations in Ph\u2010negative cells for &gt;12\u2009years. Although dysplasia in the bone marrow cells was identified, no overt transformation to myelodysplastic syndrome or acute myeloid leukemia has been observed. The cause of the CCA remains unknown in this patient, and careful observation is required.<\/jats:p>","DOI":"10.1111\/ped.12739","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T02:58:41Z","timestamp":1446778721000},"page":"53-56","source":"Crossref","is-referenced-by-count":1,"title":["Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient"],"prefix":"10.1111","volume":"58","author":[{"given":"Michiko","family":"Muraoka","sequence":"first","affiliation":[{"name":"Department of Pediatrics Okayama University Graduate School of Medicine  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Washio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Okayama University Graduate School of Medicine  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiichiro","family":"Kanamitu","sequence":"additional","affiliation":[{"name":"Department 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