{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:09:20Z","timestamp":1790809760922,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study compared selective head cooling (SHC) and whole\u2010body cooling (WBC) in newborns with hypoxic\u2013ischemic encephalopathy (HIE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective randomized small\u2010scale pilot study in newborns with HIE, born after &gt;35\u2009weeks of gestation. The patients were randomly assigned to receive SHC or WBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SHC group consisted of 17 patients, and the WBC group, 12 patients. There was no significant difference in adverse effects related to cooling therapy between the two groups. During the 12\u2009month study period, seven patients in the SHC group and four in the WBC group died, but the difference was not significant (<jats:italic>P<\/jats:italic> = 0.667). Among the patients alive at 12\u2009months after treatment, six in the SHC group and four in the WBC group had severe disabilities; the difference was not significant (<jats:italic>P<\/jats:italic> = 0.671). When the composite outcome of death or severe disability was evaluated, the difference between the SHC group (77%, n = 13) and the WBC group (67%, n = 8) was not significant (<jats:italic>P<\/jats:italic> = 0.562). Moreover, the number of survivors without disability at 12\u2009months after treatment did not differ significantly between the SHC group (n = 3) and the WBC group (n = 4; <jats:italic>P<\/jats:italic> = 0.614).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no significant differences in adverse effects, 12\u2009month neuromotor development, or mortality rate between SHC and WBC in newborns with HIE, born after &gt;35\u2009weeks of gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12747","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T19:07:27Z","timestamp":1437160047000},"page":"27-33","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of selective head cooling versus whole\u2010body cooling"],"prefix":"10.1111","volume":"58","author":[{"given":"Yalc\u0131n","family":"Celik","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, School of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytug","family":"At\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, School of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvi","family":"Gulas\u0131","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, School of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cetin","family":"Okuyaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, School of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khatuna","family":"Makharobl\u0131dze","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, School of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Sungur","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.06.009"},{"key":"e_1_2_6_4_1","first-page":"340","article-title":"Neurological outcomes at 18\u2009months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: Synthesis and meta\u2010analysis of trial data","author":"Edwards 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