{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:11:33Z","timestamp":1694754693797},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effects of valproic acid (VPA) on oxidative stress are controversial due to differences in experimental conditions. Recently, total hydroxyoctadecadienoic acid (tHODE), derived from linoleic acid, was proposed as a potent biomarker to evaluate oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects consisted of 10 new\u2010onset epilepsy patients treated with VPA. We measured plasma tHODE consecutively for 1 year to evaluate the degree of oxidative stress and then compared plasma tHODE at the beginning and the end of experiments with the peak level. Ten age\u2010matched healthy subjects were recruited as a control group and their plasma tHODE was compared to the initial plasma tHODE of the epilepsy group. Measurements were done using liquid chromatography\u2013tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean initial plasma tHODE in the epilepsy group was 165.2 \u00b1 76.8\u2009nmol\/L, which was not significantly different from that of the control group (199.3 \u00b1 62.5\u2009nmol\/L). In five epilepsy patients, plasma tHODE increased above the pathological level in 6\u2009months, but returned to normal within 1\u2009year. In the whole group, the difference plasma tHODE between peak, at the beginning and 1 year later, was significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oxidative stress generated by VPA increased temporarily, but decreased to normal after 1\u2009year. it is reasonable to be concerned about the effects of oxidative stress, especially at the start of VPA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12756","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T21:22:49Z","timestamp":1437168169000},"page":"45-48","source":"Crossref","is-referenced-by-count":1,"title":["Dynamics of hydroxyoctadecadienoic acid in epilepsy patients treated with valproic acid"],"prefix":"10.1111","volume":"58","author":[{"given":"Kohji","family":"Azumagawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seikeikai Hospital  Osaka Japan"},{"name":"Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Mino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seikeikai Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Ishida","sequence":"additional","affiliation":[{"name":"Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototada","family":"Shichiri","sequence":"additional","affiliation":[{"name":"Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Shigeri","sequence":"additional","affiliation":[{"name":"Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasukazu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Medical College  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530600959433"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.06.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.03.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/598493"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-013-9936-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.12-112"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-007-3037-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb02302.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.02.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700904"},{"key":"e_1_2_6_13_1","first-page":"65","volume-title":"Idiosyncratic 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