{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:17:04Z","timestamp":1784567824727,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the association of congenital heart disease (CHD) with serum ghrelin, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin (IL)\u20106.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010three children with CHD, hospitalized between January 2012 and September 2014 at Wuhan Women and Children's Health Care Center, were selected as the study group. Additionally, 28 healthy individuals who had physical examinations at this hospital were selected as the control group. Enzyme\u2010linked immunosorbent assay (ELISA) was used to measure serum ghrelin, TNF\u2010\u03b1 and IL\u20106. SPSS 18.0 and Comprehensive Meta\u2010analysis 2.0 were used for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was significant difference in weight, height and body mass index (BMI; all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) but not in age or sex (both <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) between the cyanotic CHD (CCHD), acyanotic CHD (ACHD) and control groups. On one\u2010way analysis of variance serum ghrelin, TNF\u2010\u03b1 and IL\u20106 in both the CCHD and ACHD groups had a tendency to be higher compared with the control group (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), whereas, on Pearson correlation analysis, there was a correlation between serum ghrelin and BMI (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and TNF\u2010\u03b1 was negatively, and IL\u20106 positively, correlated with BMI (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Meta\u2010analysis further demonstrated that serum ghrelin, TNF\u2010\u03b1 and IL\u20106 in both the CCHD and ACHD groups were higher than in the control group (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum ghrelin, TNF\u2010\u03b1 and IL\u20106 are elevated in children with CHD, and may play a role in the development and progression of CHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12773","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T14:23:17Z","timestamp":1439043797000},"page":"259-264","source":"Crossref","is-referenced-by-count":13,"title":["Elevated serum ghrelin, tumor necrosis factor\u2010\u03b1 and interleukin\u20106 in congenital heart disease"],"prefix":"10.1111","volume":"58","author":[{"given":"Dandan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Wuhan Women and Children's Health Care Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Wuhan Women and Children's Health Care Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruigeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wuhan Women and Children's Health Care Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wuhan Women and Children's Health Care Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wuhan Women and Children's Health Care Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wuhan Women and Children's Health Care Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Outpatient Department of Pediatrics No.1 Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Sun","sequence":"additional","affiliation":[{"name":"Outpatient Department of Pediatrics No.1 Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.230"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300853"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2010.02.005"},{"key":"e_1_2_7_6_1","first-page":"4189","article-title":"Heart rate variability in children with cyanotic and acyanotic congenital heart disease: Analysis by spectral and non linear indices","volume":"2012","author":"Aletti F","year":"2012","journal-title":"Conf. 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