{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:34:40Z","timestamp":1784158480196,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical course of congenital neonatal sepsis due to <jats:italic>Streptococcus pneumoniae<\/jats:italic> progresses rapidly and results in multiorgan failure with high mortality. The swift progression of the disease limits the timeframe for conventional treatment, which often requires waiting for antibiotics to show efficacy. Here, we describe the case of a very low\u2010birthweight (VLBW) female infant with congenital sepsis due to <jats:italic>S<\/jats:italic>. <jats:italic>pneumoniae<\/jats:italic> who was treated with continuous hemodiafiltration (CHDF) and polymyxin B\u2010immobilized fiber column\u2013direct hemoperfusion (PMX\u2010DHP). The infant was born at 30\u2009weeks\u2019 gestation and diagnosed with hypotension, disseminated intravascular coagulation, and pulmonary hypertension. CHDF and PMX\u2010DHP were initiated approximately 11\u2009h after birth. Mean blood pressure, oxygenation, and blood interleukin\u20106 began to improve after dialysis commencement, and the patient survived with mild sequelae. Combined CHDF and PMX\u2010DHP may be effective in treating VLBW infants with severe septic shock.<\/jats:p>","DOI":"10.1111\/ped.12776","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T06:47:03Z","timestamp":1450248423000},"page":"237-240","source":"Crossref","is-referenced-by-count":14,"title":["Effect of hemodiafiltration therapy in a low\u2010birthweight infant with congenital sepsis"],"prefix":"10.1111","volume":"58","author":[{"given":"Hironobu","family":"Tokumasu","sequence":"first","affiliation":[{"name":"Department of Consultation Kurashiki Clinical Research Institute  Okayama Japan"},{"name":"Department of Pediatrics Kurashiki Central Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Consultation Kurashiki Clinical Research Institute  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Tokumasu","sequence":"additional","affiliation":[{"name":"Department of Consultation Kurashiki Clinical Research Institute  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356986"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363691"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12029"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60799-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.1095"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80119-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12321"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1988.tb01519.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2003.11.003"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12776","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:08:16Z","timestamp":1692284896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,16]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/ped.12776"],"URL":"https:\/\/doi.org\/10.1111\/ped.12776","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,16]]}}}