{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:25:34Z","timestamp":1770704734872,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription\u2013polymerase chain reaction (RT\u2010PCR). The genotype of hMPV in each sample was identified on PCR\u2010restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at &gt;39.5\u00b0C or lasting &gt;7\u2009days were classified as the high fever (HF) group; those with fevers peaking at &lt;38.5\u00b0C and lasting &lt;72\u2009h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 \u00b1 4418 vs 4072 \u00b1 3076\/\u03bcL, <jats:italic>P<\/jats:italic> = 0.010) and C\u2010reactive protein (2.39 \u00b1 3.39 vs 0.96 \u00b1 1.77\u2009mg\/dL, <jats:italic>P<\/jats:italic> = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, <jats:italic>P<\/jats:italic> &lt; 0.001) and dyspnea (2.5% vs 15.5%, <jats:italic>P<\/jats:italic> = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two distinct clinical presentations of hMPV infection were identified in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12782","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T11:26:49Z","timestamp":1439292409000},"page":"22-26","source":"Crossref","is-referenced-by-count":12,"title":["Clinical and genetic features of human metapneumovirus infection in children"],"prefix":"10.1111","volume":"58","author":[{"given":"Ji Young","family":"Park","sequence":"first","affiliation":[{"name":"Departments of Pediatrics Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Wook","family":"Yun","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Woo","family":"Lim","sequence":"additional","affiliation":[{"name":"Neuroscience and Behavioral Biology, Emory College of Arts and Sciences Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Seok","family":"Lim","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung Sang","family":"Choi","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Chung\u2010Ang University College of Medicine  Seoul 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