{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:17:05Z","timestamp":1772849825724,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the efficacy of rituximab and low\u2010dose cyclosporine combination therapy for focal segmental glomerulosclerosis (FSGS) in children with steroid\u2010resistant nephrotic syndrome (SRNS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five FSGS children with SRNS were treated twice with rituximab and low\u2010dose cyclosporine (CyA) combination therapy (RTX\u2010CyAT). The clinical features and laboratory data were investigated before and after RTX\u2010CyAT, and the outcomes were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prednisolone (PSL) was discontinued 3\u2009months after RTX\u2010CyAT in all patients. The number of CD19\u2010positive cells decreased to &lt;1% of all white blood cells in all patients at 1\u2009month after RTX\u2010CyAT, and was maintained at this level for 259.6 \u00b1 68.2\u2009days. All patients remained in remission for the duration of the decrease in CD19\u2010positive cells to &lt;1%. Two patients also remained in remission throughout the observation period, with three patients having a single relapse at 333 \u00b1 89\u2009days (range, 231\u2013376 days) after RTX\u2010CyAT. In all patients, the mean steroid and CyA doses after RTX\u2010CyAT were lower than those before RTX\u2010CyAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RTX\u2010CyAT is effective in FSGS patients with SRNS and may ameliorate the side\u2010effects of PSL and immunosuppressive drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12804","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T13:45:37Z","timestamp":1439559937000},"page":"219-223","source":"Crossref","is-referenced-by-count":12,"title":["Rituximab and low\u2010dose cyclosporine combination therapy for steroid\u2010resistant focal segmental glomerulosclerosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Kazuhide","family":"Suyama","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syuto","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-014-1030-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.204"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0794-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.6.2188"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0133"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0814-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1191-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm128"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60541-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0640-x"},{"key":"e_1_2_6_12_1","first-page":"484","article-title":"treatment of steroid\u2010resistant nephrotic syndrome in children","volume":"21","author":"Kari JA","year":"2010","journal-title":"Saudi J. 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