{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:19:33Z","timestamp":1793110773462,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Urinary tract infections (UTI) are one of the most common bacterial infections in children and a major cause of hospitalization. In this study we investigated the clinical characteristics, causative uropathogens; their antibiotic susceptibility and resistance patterns, treatment modalities and efficacy in children hospitalized for UTI in a tertiary care setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients hospitalized for an upper UTI between March 2009 and July 2014 were enrolled. The urine culture\u2013antibiogram results and accompanying urinary tract abnormalities were recorded retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 142 patients (104 girls, 73.2%; 38 boys, 26.8%) were enrolled. Mean patient age was 32.6\u2009\u00b1\u20094.1\u2009months. History of recurrent UTI was present in 45.8% (n\u2009=\u200965), with prior hospitalization in 12.0% (n\u2009=\u200917). Frequency of vesicoureteral reflux was 18.3% (n\u2009=\u200926). Gram\u2010negative enteric microorganisms yielded growth in all culture\u2010positive UTI and the most common microorganism was<jats:italic>Escherichia coli<\/jats:italic>(n\u2009=\u2009114, 80.3%). Extended spectrum beta\u2010lactamase\u2010producing (ESBL (+)) bacterial strains were detected in 49.3% (n\u2009=\u200970), with third\u2010generation cephalosporin resistance in all and increased duration of hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of UTI with ESBL (+) bacterial strains with multi\u2010drug resistance is increasing in the hospitalized pediatric population, therefore rational use of antibiotics is essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12842","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T15:22:43Z","timestamp":1446132163000},"page":"467-471","source":"Crossref","is-referenced-by-count":37,"title":["Causative pathogens and antibiotic resistance in children hospitalized for urinary tract infection"],"prefix":"10.1111","volume":"58","author":[{"given":"Mesut","family":"Ko\u00e7ak","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"B\u00fcy\u00fckkarag\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"\u00c7elebi Tayfur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun","family":"\u00c7altik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem Yasin","family":"K\u00f6ksoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"\u00c7izmeci","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacit","family":"G\u00fcnbey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2810-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1951-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-013-1118-4"},{"key":"e_1_2_7_6_1","first-page":"409","article-title":"Diagnosis and treatment of urinary tract infections in children","volume":"83","author":"White B","year":"2011","journal-title":"Am. 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