{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:35:31Z","timestamp":1789648531342,"version":"4.0.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Infection caused by extended spectrum \u03b2\u2010lactamase (ESBL)\u2010producing\n                      <jats:italic>Enterobacteriaceae<\/jats:italic>\n                      in pediatric patients has been increasing and spreading to the community, compromising the options for effective antibiotics. This retrospective study was conducted to identify which antibiotics ESBL\u2010producing\n                      <jats:italic>Enterobacteriaceae<\/jats:italic>\n                      remain susceptible to. In addition, the prevalence of community\u2010acquired infection caused by these organisms, and the possibility of association between these organisms and septic shock, were explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Antibiotic susceptibility of ESBL\u2010producing and non\u2010ESBL\u2010producing\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      and\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      strains isolated from pediatric patients were reviewed to determine the rates of susceptibility to various antibiotics. A chart review was performed to clarify the prevalence of community\u2010acquired infection and the severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 849 strains analyzed, 40% were ESBL positive. Apart from cephalosporins, ESBL\u2010producing strains were also less likely to be susceptible to other antibiotics, such as quinolones, gentamicin, netilmicin, and cotrimoxazole, more than 90% of which were still susceptible to amikacin, carbapenems, colistin, and tigecycline. Around 20% of community\u2010acquired infections in the present study were caused by ESBL\u2010producing strains. ESBL\u2010producing strains found in the community were more likely to be susceptible to gentamicin, netilmicin, and cefepime than those found in hospital. Infection caused by ESBL\u2010producing strains was not significantly associated with septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The increase in infection caused by ESBL\u2010producing\n                      <jats:italic>Enterobacteriaceae<\/jats:italic>\n                      limits the availability of effective antibiotics. Given that carbapenems are necessary for treating serious infections, amikacin, cefepime, and piperacillin\/tazobactam are possible options for consolidative therapy or for non\u2010serious infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.12845","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T11:38:46Z","timestamp":1446118726000},"page":"338-346","source":"Crossref","is-referenced-by-count":15,"title":["Pediatric extended spectrum \u03b2\u2010lactamase infection: Community\u2010acquired infection and treatment options"],"prefix":"10.1111","volume":"58","author":[{"given":"Napapailin","family":"Sethaphanich","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pitak","family":"Santanirand","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasivimol","family":"Rattanasiri","sequence":"additional","affiliation":[{"name":"Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonnamet","family":"Techasaensiri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujittra","family":"Chaisavaneeyakorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopporn","family":"Apiwattanakul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.08.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/420816"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06301-11"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.12.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/500663"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq415"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/588082"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.05.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00622-08"},{"key":"e_1_2_7_11_1","unstructured":"Clinical and Laboratory Standards Institute.Performance Standards For Antimicrobial Susceptibility Testing. 24th informational supplement CLSI document M100\u2010S24. 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