{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:41:30Z","timestamp":1768250490735,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infant flow biphasic nasal continuous positive airway pressure (Bi\u2010NCPAP) and regular NCPAP (Re\u2010NCPAP) are equally useful with respect to the rate of successful weaning from mechanical ventilation. It remains unclear, however, whether Bi\u2010NCPAP or Re\u2010NCPAP is more effective for reducing apnea of prematurity (AOP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter randomized controlled study was conducted of 66 infants assigned to receive Bi\u2010NCPAP and 66 assigned to receive Re\u2010NCPAP for respiratory support after extubation. Primary outcome was the number of AOP events during the 48\u2009h observation period after successful extubation, defined as no reintubation and no adverse events associated with the use of NCPAP during the observation period. The secondary outcome was successful extubation. Reintubation was at the discretion of the attending physician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were similar between the two groups. The number of AOP events during the 48\u2009h observation period was significantly lower in infants with Bi\u2010NCPAP than in those with Re\u2010NCPAP (5.2\u2009\u00b1\u20096.5 vs 10.3\u2009\u00b1\u200910.9 per infant, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). The rate of successful extubation tended to be greater in those with Bi\u2010NCPAP than in those with Re\u2010NCPAP (92.4%, 61\/66 vs 80.3%, 53\/66, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.074). Adverse events occurred in only one of 132 infants: erosive dermatitis developed on the nose after application of Re\u2010NCPAP. The risk of reintubation did not differ significantly between the two groups (7.6%, 5\/66 for Bi\u2010NCPAP vs 18.2%, 12\/66 for Re\u2010NCPAP; <jats:italic>P<\/jats:italic>\u2009=\u20090.117).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bi\u2010NCPAP was superior to Re\u2010NCPAP for reduction of AOP following extubation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12854","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T11:05:58Z","timestamp":1448967958000},"page":"456-460","source":"Crossref","is-referenced-by-count":8,"title":["Effects of infant flow Bi\u2010NCPAP on apnea of prematurity"],"prefix":"10.1111","volume":"58","author":[{"given":"Chie","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ibara","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiteru","family":"Ohsone","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kimitsu Chuo Hospital  Kisarazu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Neonatology Funabashi Central Hospital  Funabashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"},{"name":"Department of Neonatology Fukuda Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Gifu Prefectural General Medical Center  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Maede","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"},{"name":"Department of Neonatology Fukuda Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9810071"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282f63953"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0653"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054065"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073679"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199811)26:5<349::AID-PPUL8>3.0.CO;2-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200205"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.1.13"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.4.638"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02525.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-43"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/251047"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.2.F86"},{"key":"e_1_2_8_16_1","first-page":"1196","article-title":"Nasal intermittent positive\u2010pressure ventilation offers no advantages over nasal continuous positive airway pressure in apnea of prematurity","volume":"143","author":"Ryan CA","year":"1989","journal-title":"Am. 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