{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:11:06Z","timestamp":1790885466604,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methylmalonic acidemia (MMA) is an inborn error of metabolism caused by either deficiency of the enzyme methylmalonyl\u2010CoA mutase or a defect in adenosyl\u2010cobalamin synthesis. Chronic kidney disease is its common complication and, in combination with persistent acidosis, leads to hyperuricemia. Symptomatic hyperuricemia or gout, however, has not been reported in MMA. We herein report two pediatric cases of MMA caused by <jats:italic>MMAB<\/jats:italic> mutations (cblB defect) with renal tubular acidosis, chronic kidney disease, hyperuricemia, and gout. The clinical findings of gout in these cases included recurrent first metatarsophalangeal arthritis and\/or tophi. The patients responded to treatment with colchicine and allopurinol.<\/jats:p>","DOI":"10.1111\/ped.12857","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T10:11:48Z","timestamp":1457431908000},"page":"501-503","source":"Crossref","is-referenced-by-count":11,"title":["Juvenile gout in methylmalonic acidemia"],"prefix":"10.1111","volume":"58","author":[{"given":"Sirirat","family":"Charuvanij","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirut","family":"Pattaragarn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanee","family":"Wisuthsarewong","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithiwat","family":"Vatanavicharn","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0839-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.08.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(03)00106-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.05.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(64)90104-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1996.tb01935.x"},{"key":"e_1_2_6_8_1","first-page":"1230","article-title":"Methylmalonic acidemia: 6\u2009years' clinical experience with two variants unresponsive to vitamin B12 therapy","volume":"120","author":"Whelan DT","year":"1979","journal-title":"Can. 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