{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:15:22Z","timestamp":1758946522491},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Young Scientists","award":["23791234"],"award-info":[{"award-number":["23791234"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persistent patent ductus arteriosus (PDA) is a frequent complication in preterm infants. Single nucleotide polymorphisms (SNP) in several genes, including angiotensin II receptor, type 1 (<jats:italic>AGTR1<\/jats:italic>), transcription factor AP\u20102 beta (<jats:italic>TFAP2B<\/jats:italic>) and tumor necrosis factor receptor\u2010associated factor 1 (<jats:italic>TRAF1<\/jats:italic>), have been reported to be associated with PDA in preterm infants. The aim of this study was to evaluate the relationships between PDA in preterm infants and polymorphisms in <jats:italic>AGTR1<\/jats:italic>, <jats:italic>TFAP2B<\/jats:italic> and <jats:italic>TRAF1<\/jats:italic> in the Japanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects consisted of 107 preterm infants with gestational age &lt;32\u2009weeks. Extremely low\u2010birthweight infants were treated with prophylactic indomethacin during the first 24\u2009h after birth. Five SNP, namely, rs5186 in <jats:italic>AGTR1<\/jats:italic>, rs987237 and rs6930924 in <jats:italic>TFAP2B<\/jats:italic>, and rs1056567 and rs10985070 in <jats:italic>TRAF1<\/jats:italic>, were genotyped using TaqMan SNP genotyping assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the distributions of the genotypes and allele frequencies of all studied SNP between the PDA group (n\u2009=\u200946) and the non\u2010PDA group (n\u2009=\u200961).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no significant associations between the studied SNP and the incidence of PDA in Japanese preterm infants. These SNP may not be clinically important predisposing factors for PDA in Japanese preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12861","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T10:02:50Z","timestamp":1448877770000},"page":"461-466","source":"Crossref","is-referenced-by-count":4,"title":["Single nucleotide polymorphisms in <i>AGTR1<\/i>, <i>TFAP2B<\/i>, and <i>TRAF1<\/i> are not associated with the incidence of patent ductus arteriosus in Japanese preterm infants"],"prefix":"10.1111","volume":"58","author":[{"given":"Koya","family":"Kawase","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokio","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology Nagoya City University Graduate School of Medical 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