{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:27:52Z","timestamp":1759411672038},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infants with influenza, particularly those younger than 1 year of age, are at high risk of developing a severe case or of dying. Recently, owing to the spread of pandemic influenza A (H1N1) 2009, the Advisory Committee on Immunization Practices recommended maternal immunization to reduce the risk of influenza infection in pregnant women and infants. Such reporting is rare in <jats:styled-content style=\"fixed-case\">Japan<\/jats:styled-content>. The aim of this study was therefore to investigate the effect on the newborn of influenza vaccination of pregnant women in <jats:styled-content style=\"fixed-case\">Japan<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 200 infants who were born to healthy mothers at Kobayashi Ladies Clinic during influenza season from <jats:styled-content style=\"fixed-case\">November<\/jats:styled-content> 2010 to <jats:styled-content style=\"fixed-case\">April<\/jats:styled-content> 2011. The incidence of fever and laboratory\u2010confirmed influenza was assessed in the infants for the 6 months after their birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 200 infants, four were excluded from this study due to loss to follow up. The 106 infants in the group whose mothers received the influenza vaccine (vaccinated group) before parturition were compared with the 90 infants in the group whose mothers did not receive the influenza vaccine (non\u2010vaccinated group). Fever was noted in 36 infants (34.0%) in the vaccinated group and in 47 infants (52.2%) in the non\u2010vaccinated group (<jats:italic>P<\/jats:italic> &lt; 0.007), and the incidence of influenza was 0 (0%) and 5 (5.6%), respectively (<jats:italic>P<\/jats:italic> = 0.019). The incidence of fever and influenza among infants was significantly lower in the vaccinated group compared with the non\u2010vaccinated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal influenza immunization should be actively recommended in <jats:styled-content style=\"fixed-case\">Japan<\/jats:styled-content> to protect newborns from influenza viruses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12888","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T03:41:18Z","timestamp":1450237278000},"page":"709-713","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of maternal influenza immunization in young infants in <scp>Japan<\/scp>"],"prefix":"10.1111","volume":"58","author":[{"given":"Tetsu","family":"Sugimura","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Allergology Sugimura Children's Medical Clinic  Chikugo Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagai Children's Clinic  Takamatsu Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Anesthesiology Kobayashi Ladies Clinic  Chikugo Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001273420401"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051721"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2679"},{"key":"e_1_2_7_5_1","first-page":"1233","article-title":"Influenza\u2010associated pediatric deaths: United States, September 2010\u2010August 2011","volume":"60","author":"Centers for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR Morb. 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