{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:55:13Z","timestamp":1790434513257,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Achondroplasia (ACH) and hypochondroplasia (HCH) are the most common form of short\u2010limb skeletal dysplasias caused by activated <jats:italic>fibroblast growth factor receptor 3<\/jats:italic> (<jats:italic>FGFR3<\/jats:italic>) signaling. Although decreased bone mass was reported in gain\u2010of\u2010function mutation in <jats:italic>Fgfr3<\/jats:italic> mice, both disorders have never been described as osteoporotic. In the present study, we evaluated bone mineral density (BMD) in ACH and HCH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured spinal BMD (L1\u2013L4) in 18 ACH and four HCH patients with an average age of 19.8 \u00b1 7.5 years (range, 10\u201333 years). BMD Z\u2010score in each individual was calculated for normalizing age and gender. Correlation between body mass index (BMI) and BMD was analyzed. Moreover, BMD and Z\u2010score were compared between ACH patients and HCH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average BMD of ACH\/HCH patients was 0.805 \u00b1 0.141 g\/cm<jats:sup>2<\/jats:sup> (range, 0.554\u20131.056 g\/cm<jats:sup>2<\/jats:sup>), resulting in an average Z\u2010score of \u22121.1 \u00b1 0.8 (range, \u22122.4 to 0.6) of the standard value. A slightly positive correlation was observed between BMI and BMD (<jats:italic>r<\/jats:italic> = 0.45; <jats:italic>P<\/jats:italic> = 0.13). There was no significant difference in BMD and Z\u2010score between ACH and HCH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spinal BMD was reduced in ACH\/HCH patients, and was mildly correlated with individual BMI. We should carefully monitor BMD and examine osteoporosis\u2010related symptoms in adolescent and adult ACH\/HCH patients. \u00a9 2016 Japan Pediatric Society.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12890","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T16:22:46Z","timestamp":1451492566000},"page":"705-708","source":"Crossref","is-referenced-by-count":24,"title":["Low bone mineral density in achondroplasia and hypochondroplasia"],"prefix":"10.1111","volume":"58","author":[{"given":"Masaki","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitoh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Graduate School of Medicine  Nagoya 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