{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:15:39Z","timestamp":1777590939638,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the relationship between umbilical cord blood interleukin (IL)\u20106 concentration and preterm morbidity and mortality in premature infants born with fetal inflammatory response syndrome (FIRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational study included 84 preterm infants with a gestational age of 24\u201336 weeks who had been admitted to the neonatal intensive care unit (NICU). FIRS was defined as umbilical cord blood IL\u20106 &gt; 11 pg\/mL. In premature infants with FIRS, morbidities (multiple organ failure [MOF], respiratory distress syndrome [RDS], patent ductus arteriosus, intraventricular hemorrhage, bronchopulmonary dysplasia, retinopathy of prematurity) and death were evaluated. Critical umbilical cord blood IL\u20106 concentrations for the development of RDS, death, and for MOF were determined in premature infants with FIRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two infants with IL\u20106 concentration &gt; 11 pg\/mL constituted the FIRS group. Thirty\u2010two infants without FIRS served as a control group. RDS, MOF, and mortality were significantly higher in the FIRS group (<jats:italic>P<\/jats:italic> = 0.001, <jats:italic>P<\/jats:italic> = 0.001, and <jats:italic>P<\/jats:italic> = 0.005, respectively). Umbilical cord blood IL\u20106 concentration &gt; 26.7 pg\/mL in the FIRS group was found to be predictive of RDS, with 70% sensitivity and 85% specificity. Umbilical cord blood IL\u20106 concentration &gt; 37.7 pg\/mL was found to be predictive of death, with 78.6% sensitivity and 60% specificity. The predictive value of IL\u20106 for the development of MOF was 17.5 pg\/mL, with 91% sensitivity and 66% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Umbilical cord blood IL\u20106 concentration &gt; 26.7, 37.7, and 17.5 pg\/mL in premature infants with FIRS was found to be predictive for RDS, death, and MOF, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12895","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T19:52:39Z","timestamp":1451505159000},"page":"850-854","source":"Crossref","is-referenced-by-count":15,"title":["Morbidity in preterm infants with fetal inflammatory response syndrome"],"prefix":"10.1111","volume":"58","author":[{"given":"Elif","family":"Ozalkaya","sequence":"first","affiliation":[{"name":"Zeynep Kamil Maternity and Children's Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcner","family":"Karatekin","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Maternity and Children's Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevilay","family":"Topcuo\u011flu","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Maternity and Children's Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Maternity and Children's Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahri","family":"Oval\u0131","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Maternity and Children's Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3386-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.1.18.25"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70272-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.08.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70299-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.46"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.08.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.109035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70585-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1471-0528.2003.00063.x","article-title":"Intrauterine infection and the development of cerebral palsy","volume":"110","author":"Yoon BH","year":"2003","journal-title":"Br. 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