{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T10:32:18Z","timestamp":1711967538169},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The best time for vaccination in infants with congenital heart disease (CHD) after cardiopulmonary bypass (CPB) surgery is unclear, but it is important to prevent Haemophilus influenzae type b (Hib) infection in infants with CHD after CPB surgery. To identify the best time for Hib vaccination in infants with CHD after CPB surgery, we investigated the immunological status, and the efficacy and safety of Hib vaccination after CPB surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen subjects who underwent surgical correction of ventricular septal defect with CPB were investigated. Immunological status and cytokines were analyzed before surgery, 2 months after surgery, and before Hib booster vaccination. Hib\u2010specific IgG was also measured to evaluate the effectiveness of vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunological status before and 2 months after surgery (e.g.\u00a0whole blood cells and lymphocyte subset profile) was within the normal range and no subjects had hypercytokinemia. Additionally, all subjects who received Hib vaccination at 2\u20133 months after CPB surgery had effective serum Hib\u2010specific IgG level for protection against Hib infection without any side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CPB surgery does not influence acquired immunity and Hib vaccination may be immunologically safe to perform at 2 months after CPB surgery. Hib vaccination at 2\u20133 months after CPB surgery was effective in achieving immunization for infants with simple left\u2013right shunt\u2010type CHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12899","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T06:22:39Z","timestamp":1451542959000},"page":"691-697","source":"Crossref","is-referenced-by-count":7,"title":["Timing of Haemophilus influenzae type b vaccination after cardiac surgery"],"prefix":"10.1111","volume":"58","author":[{"given":"Manabu","family":"Takanashi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Mineo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumito","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Nakahata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kagami","family":"Miyaji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)01025-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.830174"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.19.2376"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90001-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90265-J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950070037"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200116001-00006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v1.i3.8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32835dce2f"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951105000545"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000108220.94201.1a"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230405"},{"key":"e_1_2_7_14_1","first-page":"87","volume-title":"Epidemiology and Prevention of Vaccine\u2010Preventable Diseases","author":"Centers for Disease Control and Prevention: Haemophilis influenzae type b","year":"2012"},{"key":"e_1_2_7_15_1","first-page":"445","article-title":"WHO position paper on Haemophilus influenzae type b conjugate vaccines","volume":"81","author":"World Health Organization","year":"2006","journal-title":"Wkly Epidemiol. 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