{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:45:24Z","timestamp":1789447524509,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between chorioamnionitis (CAM) and neonatal mortality has been extensively investigated, but that of maternal pre\u2010eclampsia and neonatal mortality is unclear. We investigated neonatal mortality and morbidity of maternal pre\u2010eclampsia and clinical CAM in extremely premature infants using data from a population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data obtained from the Neonatal Research Network in <jats:styled-content style=\"fixed-case\">Japan<\/jats:styled-content>, a population\u2010based cohort study (<jats:italic>n<\/jats:italic> = 18\u00a0900) conducted to clarify the clinical characteristics and morbidity of very low\u2010birthweight infants. Patients were divided into four diagnosis\u2010based groups for comparative analysis: sole pre\u2010eclampsia; sole clinical CAM; concurrent pre\u2010eclampsia and clinical CAM; and non\u2010diagnosis (of pre\u2010eclampsia and clinical CAM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mortality was higher in the pre\u2010eclampsia groups compared with the groups without (18.3%, 84\/459 vs 14.0%, 567\/4059; OR, 1.38; 95%CI: 1.07\u20131.78). In contrast, mortality was not affected by presence of clinical CAM (with, 13.7% 182\/1328 vs without, 15.0% 469\/3190; OR, 0.92; 95%CI: 0.77\u20131.11). With regard to small for gestational age, the mortality rate increased by two\u2013three\u2010fold as gestational week decreased. The complication survival rate in the whole group was 35% (1135\/3218).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal pre\u2010eclampsia is associated with poor prognosis in extremely premature infants. We also need to deliberate on the trade\u2010off between the advantages of early rescue from pre\u2010eclampsia and risk of prematurity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12905","type":"journal-article","created":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T17:51:05Z","timestamp":1451757065000},"page":"578-583","source":"Crossref","is-referenced-by-count":17,"title":["Impact of pre\u2010eclampsia in extremely premature infants: Population\u2010based study"],"prefix":"10.1111","volume":"58","author":[{"given":"Hironobu","family":"Tokumasu","sequence":"first","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health Kyoto University  Kyoto Japan"},{"name":"Department of Consultation Kurashiki Clinical Research Institute  Okayama Japan"},{"name":"Department of Pediatrics Kurashiki Central Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Tokumasu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kurashiki Central Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"EXPRESS Group FellmanV Hellstr\u00f6m\u2010WestasLet al.One\u2010year survival of extremely preterm infants after active perinatal care inSweden. 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