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Intrapleural fibrinolytic therapy with urokinase is an effective and non\u2010invasive treatment option that avoids surgical intervention, although its use in neonates has not been studied extensively. In this report, we describe the case of a 13\u2010day\u2010old male neonate with <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> sepsis and pneumonia, which rapidly progressed to parapneumonic effusion and pleural empyema. After inadequate response to i.v. antibiotics and chest tube drainage, the patient was successfully treated with intrapleural urokinase.<\/jats:p>","DOI":"10.1111\/ped.12906","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T09:20:52Z","timestamp":1457428852000},"page":"616-619","source":"Crossref","is-referenced-by-count":8,"title":["Intrapleural urokinase therapy in a neonate with pleural empyema"],"prefix":"10.1111","volume":"58","author":[{"given":"Lily Myung\u2010Jin","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Severance Children's Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunha","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children's Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taehwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Health Insurance Medical Center Ilsan Hospital  Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Won","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Health Insurance Medical Center Ilsan Hospital  Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050902994630"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02730828"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.07.034"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0383-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3935"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.048108"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.030676"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.684674"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10212"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(200012)30:6<493::AID-PPUL10>3.0.CO;2-O"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12906","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:24:49Z","timestamp":1694658289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,8]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/ped.12906"],"URL":"https:\/\/doi.org\/10.1111\/ped.12906","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,8]]}}}