{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:56:26Z","timestamp":1760622986057},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate whether <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> plays a role in the pathogenesis and severity of non\u2010cystic fibrosis bronchiectasis, and its relationship with gastroesophageal reflux (GER).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one patients and 16 controls between 5 and 18 years of age were enrolled. <jats:italic>H.\u00a0pylori<\/jats:italic> was investigated on polymerase chain reaction and culture in gastric juice (GJ) and bronchoalveolar lavage fluid (BALF). Urea breath test (UBT) was also used for defining <jats:italic>H.\u00a0pylori<\/jats:italic> infection. GER was detected on 24\u00a0h pH monitoring or scintigraphy. Computed tomography (CT) scoring was used to quantify the severity and extent of bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients (22%) in the bronchiectasis group (BG) and three patients (18.8%) in the control group (CG) had <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive BALF. Sixteen BG patients (39%) and seven CG patients (43.8%) had <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive GJ. UBT was positive in 11 BG patients (26.8%) and in three CG patients (18.8%). <jats:italic>H.\u00a0pylori<\/jats:italic> positivity in BALF, GJ and UBT was not significantly different between the two groups (<jats:italic>P<\/jats:italic> &gt; 0.05). Six patients with GER and five patients without GER in BG had <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive BALF and GJ (<jats:italic>P<\/jats:italic> = 0.827). No association was found between BALF <jats:italic>H. pylori<\/jats:italic> positivity and forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) in BG. CT score was significantly higher in BG patients with <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive compared with <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative BALF (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is not associated with the pathogenesis of bronchiectasis but it may be responsible for the severity of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12918","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T20:17:58Z","timestamp":1452802678000},"page":"894-898","source":"Crossref","is-referenced-by-count":2,"title":["Does <scp><i>Helicobacter pylori<\/i><\/scp> play a role in the pathogenesis of non\u2010cystic fibrosis bronchiectasis?"],"prefix":"10.1111","volume":"58","author":[{"given":"Turkan","family":"Ayd\u0131n Teke","sequence":"first","affiliation":[{"name":"Infectious Disease Dr Sami Ulus Maternity and Children's Research and Education Hospital  Altinda\u011f Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakut","family":"Aky\u00f6n","sequence":"additional","affiliation":[{"name":"Microbiology Hacettepe University Faculty of Medicine, Hacettepe  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Hacettepe University Faculty of Medicine, Hacettepe  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Ozen","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology, and Nutrition Hacettepe University Faculty of Medicine, Hacettepe  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Hacettepe University Faculty of Medicine, Hacettepe  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nural","family":"Kiper","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Hacettepe University Faculty of Medicine, Hacettepe  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Ozcelik","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Hacettepe University Faculty of Medicine, Hacettepe  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200104000-00014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00127704"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00634.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14613459"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.7556\/jaoa.1993.93.1.87"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.1.62"},{"key":"e_1_2_5_8_1","first-page":"235","volume-title":"Jawetz, Melnick and Adelberg's Medical Microbiology,","author":"Brooks GF","year":"2010"},{"key":"e_1_2_5_9_1","volume-title":"Current Protocols In Molecular Biology","author":"Wilson K","year":"1987"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.1.192-200.1992"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.6.540"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2187-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/MPG.0b013e3181b7f563","article-title":"Pediatric gastroesophageal reflux clinical practice guidelines: Joint recommendations of the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition","volume":"49","author":"Vandenplas Y","year":"2009","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"e_1_2_5_14_1","first-page":"1004","article-title":"Radionuclide gastroesophageal motor studies","volume":"45","author":"Mariani G","year":"2004","journal-title":"J. Nucl. Med."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9712104"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb02843.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2006.11.010"},{"key":"e_1_2_5_18_1","first-page":"114","article-title":"Helicobacter pylori\n                   infection in Turkish preschool and school children: Role of socioeconomic factors and breast feeding","volume":"45","author":"Ertem D","year":"2003","journal-title":"Turk. J. Pediatr."},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29545"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30313.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02172.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29332"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20110"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12918","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:16:20Z","timestamp":1694657780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ped.12918"],"URL":"https:\/\/doi.org\/10.1111\/ped.12918","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,8]]}}}