{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:27Z","timestamp":1762875747725},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many pregnant women take vitamin supplements during pregnancy. The aim of this paper was to clarify the effects of dietary supplementation prior to and\/or during pregnancy on child behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective birth cohort study from pregnancy to 3 years of age involving 1271 pairs of <jats:styled-content style=\"fixed-case\">Japanese<\/jats:styled-content> pregnant women and their newborns, was carried out. The women completed a self\u2010administered questionnaire during the third trimester of pregnancy. To evaluate deviations in child behavior as an endpoint, each mother completed the <jats:styled-content style=\"fixed-case\">Japanese<\/jats:styled-content> Child Behavior Checklist for ages 2\u20133 years after 3 years of birth. Participant characteristics were compared between supplement takers and non\u2010takers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among many kinds of supplements, intake of supplemental vitamin A\/\u03b2\u2010carotene prior to and\/or during pregnancy was associated with hazardous effects on child behavior at 3 years of age (total <jats:italic>t<\/jats:italic>\u2010score, <jats:italic>P<\/jats:italic> = 0.003; internal <jats:italic>t<\/jats:italic>\u2010score, <jats:italic>P<\/jats:italic> = 0.027; external <jats:italic>t<\/jats:italic>\u2010score, <jats:italic>P<\/jats:italic> = 0.013). This association held true even after adjusting for age, number of deliveries, infertility treatment, consumption of fast food, smoking status, maternal and paternal education, maternal and paternal income, gestational age at birth, anthropometry at birth (weight, height, head circumference and body circumference), and the State\u2013Trait Anxiety Inventory at 3 years of age by means of multiple imputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intake of supplemental vitamin A prior to and\/or during pregnancy may worsen child behavior at 3 years of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12925","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T12:54:24Z","timestamp":1452862464000},"page":"855-861","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal vitamin A supplementation associated with adverse child behavior at 3 years in a prospective birth cohort in <scp>Japan<\/scp>"],"prefix":"10.1111","volume":"58","author":[{"given":"Yohei","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Division of Molecular Epidemiology Jikei University School of Medicine  Tokyo Japan"},{"name":"St Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Akutsu","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology Jikei University School of Medicine  Tokyo Japan"},{"name":"St Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Koide","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sado General Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Urashima","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology Jikei University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics Jikei University School of Medicine  Tokyo 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