{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:23:36Z","timestamp":1774715016030,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blue rubber bleb nevus syndrome (BRBNS) involves cutaneous vascular malformation characterized by multiple venous malformations. This commonly affects the skin and gastrointestinal tract. BRBNS is associated with anemia and occasionally involves orthopedic manifestations. A 6\u2010year\u2010old boy was referred to hospital for evaluation of anemia. He presented with a rubber\u2010like soft\u2010tissue mass in the left knee and the right side of the neck, recurrent pain, and fixed flexion contracture of the knee. Blood examination indicated consumption coagulopathy and anemia caused by not only iron\u2010deficiency anemia but also microangiopathy. Endoscopy of the gastrointestinal tract indicated multiple bluish\u2010black sessile venous malformations. Ultrasonography and magnetic resonance imaging of the knee showed intra\u2010articular and intramuscular involvement. Based on these findings, BRBNS with knee joint disorder was diagnosed. With regard to vascular malformations, like other diseases such as inflammatory arthropathy, ultrasonography of the joint may become a new diagnostic approach for evaluating orthopedic manifestations.<\/jats:p>","DOI":"10.1111\/ped.12929","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T14:33:24Z","timestamp":1461767604000},"page":"740-743","source":"Crossref","is-referenced-by-count":8,"title":["Blue rubber bleb nevus syndrome with knee joint disorder"],"prefix":"10.1111","volume":"58","author":[{"given":"Takehiko","family":"Doi","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Hospital Organization, Fukuoka\u2010Higashi Medical Center  Koga City, Fukuoka Japan"},{"name":"Department of Pediatrics Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Masumoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization, Fukuoka\u2010Higashi Medical Center  Koga City, Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoshi","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization, Fukuoka\u2010Higashi Medical Center  Koga City, Fukuoka Japan"},{"name":"Department of Pediatrics Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization, Fukuoka\u2010Higashi Medical Center  Koga City, Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization, Fukuoka\u2010Higashi Medical Center  Koga City, Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3673"},{"key":"e_1_2_6_3_1","first-page":"267","article-title":"Case of naevus involving the parotid gland, and causing death from suffocation. Naevi of the viscera","volume":"11","author":"Gascoyen M","year":"1860","journal-title":"Trans. Pathol. 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