{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:54Z","timestamp":1761017154335},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute encephalitis with refractory, repetitive partial seizures (AERRPS) is characterized by repetitive seizures during the acute and chronic phases and has a poor neurological outcome. Burst\u2010suppression coma via continuous i.v. infusion of a short\u2010acting barbiturate is used to terminate refractory seizures, but the severe side\u2010effects of short\u2010acting barbiturates are problematic. We report on a 9\u2010year\u2010old boy with AERRPS who was effectively treated with very\u2010high\u2010dose phenobarbital (VHDPB) combined with intermittent short\u2010acting barbiturates. VHDPB side\u2010effects were mild, especially compared with those associated with continuous i.v. infusion of short\u2010acting barbiturates (dosage, 40\u201375 mg\/kg\/day; maximum blood level, 290 \u03bcg\/mL). Using VHDPB as the main treatment, short\u2010acting barbiturates were used intermittently and in small amounts. This is the first report to show that VHDPB, combined with intermittent short\u2010acting barbiturates, can effectively treat AERRPS. After treatment, convulsions were suppressed and daily life continued, but intellectual impairment and high\u2010level dysfunction remained.<\/jats:p>","DOI":"10.1111\/ped.12934","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T06:48:14Z","timestamp":1465368494000},"page":"750-753","source":"Crossref","is-referenced-by-count":5,"title":["High\u2010dose phenobarbital with intermittent short\u2010acting barbiturates for acute encephalitis with refractory, repetitive partial seizures"],"prefix":"10.1111","volume":"58","author":[{"given":"Takashi","family":"Uchida","sequence":"first","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Nishio","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurika","family":"Numata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ishinomaki Red Cross Hospital  Ishinomaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakaba","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Takuto Rehabilitation Center for Children  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Haginoya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Takuto Rehabilitation Center for Children  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ohura","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01198.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(89)90039-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.7.1035"},{"issue":"9","key":"e_1_2_6_5_1","first-page":"65","article-title":"Nonintravenous high\u2010dose phenobarbital add\u2010on therapy for refractory status epilepticus unable to discontinue intravenous infusion of general anesthetics","volume":"43","author":"Kenji S","year":"2002","journal-title":"Epilepsia"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.06.014"},{"key":"e_1_2_6_7_1","first-page":"317","volume-title":"The Textbook of Anesthesia","author":"Reves JG","year":"2004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2009.02.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02703.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03250.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199502000-00028"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12934","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:52:43Z","timestamp":1694656363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ped.12934"],"URL":"https:\/\/doi.org\/10.1111\/ped.12934","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,8]]}}}