{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:44:24Z","timestamp":1694756664828},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bacterial colonization during wheezing in early childhood has been associated with short\u2010term relapses of wheezing, but no study has addressed the effects of <jats:italic>Streptococcus pneumoniae<\/jats:italic> colonization on long\u2010term outcome of wheezing. The aim of the present study was therefore to evaluate whether pneumococcal (PNC) colonization during the first wheezing episode in early childhood is a determinant of asthma, atopy or lung function in the long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 1981\u201382 83 infants were hospitalized for first wheezing episode at &lt;24\u00a0months of age. PNC colonization was defined as positive nasopharyngeal aspirate for <jats:italic>S. pneumoniae<\/jats:italic> either in culture or antigen detection on hospital admission. Atopy and repeated wheezing or asthma were diagnosed on all follow\u2010up visits from infancy until the age of 28\u201331\u00a0years. Spirometry was conducted at the ages of 8\u201310, 18\u201320 and 28\u201331\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PNC colonization was found in 25\/83 infants (30%) during hospitalization for wheezing in infancy. PNC colonization was not associated with later atopy, repeated wheezing, asthma or lung function at any time during the 30\u00a0year follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PNC colonization during the first wheezing episode in early childhood is not a determinant of subsequent wheezing or later asthma, atopy or lung function in childhood, adolescence or adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12939","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T08:39:03Z","timestamp":1454402343000},"page":"831-835","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term effects of pneumococcal colonization during early childhood wheezing"],"prefix":"10.1111","volume":"58","author":[{"given":"Katri","family":"Backman","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"},{"name":"Department of Pediatrics University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eija","family":"Piippo\u2010Savolainen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hertta","family":"Ollikainen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Pelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Koskela","sequence":"additional","affiliation":[{"name":"Center of Medicine and Clinical Research, Division of Pulmonology Kuopio University Hospital  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"Pediatric Research Centre Tampere University and Tampere University Hospital  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.11.1070"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22842"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4978"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16f21.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.030"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf506"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1075-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03147.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60615-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1986.tb10230.x"},{"key":"e_1_2_7_12_1","first-page":"628","article-title":"A 2\u2010 to 3\u2010year outcome after bronchiolitis","volume":"147","author":"Korppi M","year":"1993","journal-title":"Am. 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