{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:18:17Z","timestamp":1783675097090,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Focal glomerulosclerosis (FGS) is a histologic entity that causes significant proteinuria in children. Although its etiology varies, recent reports indicated that some young male patients with FGS had underlying Dent disease. We describe the case of a 14\u2010year\u2010old <jats:styled-content style=\"fixed-case\">Japanese<\/jats:styled-content> boy who presented with persistent non\u2010nephrotic range proteinuria, hematuria, and renal insufficiency. The patient was initially diagnosed as having FGS associated with scattered tubulointerstitial fibrosis. Although he had neither nephrocalcinosis nor family history of renal disease including urolithiasis, increased excretion of urinary \u03b2<jats:sub>2<\/jats:sub> microglobulin was noted. Genetic analysis for Dent disease indicated a mutation (c.726 + 1G &gt; A) in Chloride Channel, Voltage\u2010Sensitive 5 (<jats:italic>CLCN5<\/jats:italic>). Given a recent hypothesis that Dent disease may be underrecognized in children with FGS, a careful diagnostic evaluation for possible underlying Dent disease should be considered in young boys who present with persistent albuminuria associated with high\u2010grade low\u2010molecular\u2010weight proteinuria.<\/jats:p>","DOI":"10.1111\/ped.12944","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T06:57:47Z","timestamp":1466492267000},"page":"747-749","source":"Crossref","is-referenced-by-count":12,"title":["Does Dent disease remain an underrecognized cause for young boys with focal glomerulosclerosis?"],"prefix":"10.1111","volume":"58","author":[{"given":"Kaori","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shojiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Tsuruga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Joh","sequence":"additional","affiliation":[{"name":"Department of School Health Science, Faculty of Education Hirosaki University  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital  Hirosaki Japan"},{"name":"Department of Pathology Tohoku University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-28"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1657-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00198.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft394"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00900207"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1299-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2824-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-015-0152-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP62306"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1578-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1362-z"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12944","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:52:55Z","timestamp":1694656375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,21]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ped.12944"],"URL":"https:\/\/doi.org\/10.1111\/ped.12944","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,21]]}}}